| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Outer dense fiber protein 2-like, ODF2L, KIAA1229 |
| Entrez GeneID | 57489 |
| WB Predicted band size | 73.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ODF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-572 amino acids from the C-terminal region of human ODF2L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ODF2L抗体的模拟参考文献示例(请注意，这些文献为假设性示例，实际引用时请核实真实来源)：
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1. **文献名称**: "ODF2L/Cenexin regulates centriolar satellite integrity and ciliogenesis"
**作者**: Müller H, et al.
**摘要**: 利用ODF2L特异性抗体，本研究揭示了ODF2L在维持中心粒卫星颗粒稳定性中的作用，并证明其缺失会导致纤毛形成缺陷，影响细胞信号传导。
2. **文献名称**: "Characterization of ODF2L antibody for detecting centriole-associated protein complexes"
**作者**: Tanaka R, et al.
**摘要**: 开发了一种高特异性ODF2L抗体，通过免疫共沉淀和超分辨率显微镜技术，验证了ODF2L与中心体蛋白Cep170的相互作用，为研究细胞分裂机制提供工具。
3. **文献名称**: "ODF2L expression correlates with ciliary dysfunction in polycystic kidney disease models"
**作者**: Chen J, et al.
**摘要**: 通过ODF2L抗体标记，发现其在多囊肾小鼠模型中表达异常，提示ODF2L可能通过调控纤毛结构参与疾病进展，为治疗靶点提供依据。
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**备注**：以上文献为示例，建议通过PubMed或Google Scholar以关键词“ODF2L antibody”“Cenexin function”等检索真实研究。如需进一步协助定位具体文献，请提供更多背景信息。
**Background of ODF2L Antibody**
ODF2L (Outer Dense Fiber Protein 2-Like), also known as Cenexin, is a structural protein initially identified for its role in sperm tail formation, where it contributes to the stability of the outer dense fibers in sperm flagella. Beyond reproduction, ODF2L is ubiquitously expressed and plays critical roles in centrosome maturation, ciliogenesis, and cell cycle regulation. It shares homology with ODF2 but contains a unique C-terminal extension essential for recruiting microtubule-modifying enzymes to the centrosome, thereby influencing mitotic spindle organization.
Antibodies targeting ODF2L are vital tools for studying its localization and function in cellular processes. They are widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to investigate centrosome dynamics, primary cilia formation, and cell division mechanisms. Dysregulation of ODF2L has been linked to ciliopathies, infertility, and cancer, highlighting its biomedical relevance. Research utilizing ODF2L antibodies has advanced understanding of how centrosomal defects contribute to disease, making these reagents essential in both basic and translational studies.
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