| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transmembrane protein 70, mitochondrial, TMEM70 |
| Entrez GeneID | 54968 |
| WB Predicted band size | 29.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TMM70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the C-terminal region of human TMM70. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于学术文献风格的虚构参考文献示例(请注意，TMM70抗体相关研究较为前沿，以下内容为合理推测性描述，建议通过PubMed或Google Scholar核实真实文献)：
1. **文献名称**: "TMM70 as a novel biomarker in colorectal cancer: diagnostic and prognostic implications"
**作者**: Li, X., et al.
**摘要**: 本研究通过免疫组化分析发现TMM70抗体在结直肠癌组织中高表达，且与肿瘤分期和转移相关。实验表明TMM70可作为潜在的诊断标志物，其表达水平与患者生存率显著相关。
2. **文献名称**: "Mechanistic insights into TMM70-mediated tumor immune evasion"
**作者**: Wang, Y., et al.
**摘要**: 该研究揭示TMM70通过调控PD-L1表达促进肿瘤免疫逃逸。使用TMM70抗体阻断实验可增强CD8+ T细胞对肿瘤细胞的杀伤作用，为免疫治疗提供新靶点。
3. **文献名称**: "Development of a high-affinity monoclonal TMM70 antibody for therapeutic applications"
**作者**: Smith, J.R., et al.
**摘要**: 报道了一种新型人源化TMM70单克隆抗体的开发，体外实验显示其能有效抑制肿瘤细胞增殖并诱导凋亡，动物模型证实其可降低乳腺癌移植瘤体积。
4. **文献名称**: "TMM70 expression correlates with chemotherapy resistance in gastric cancer"
**作者**: Tanaka, K., et al.
**摘要**: 通过回顾性队列研究发现，TMM70高表达患者对5-FU化疗敏感性降低，机制研究提示其可能通过激活AKT/mTOR通路介导耐药性，抗体中和实验可部分逆转耐药表型。
注：以上文献为基于领域知识的模拟内容，实际研究请以权威数据库(如PubMed)检索为准，建议使用关键词"TMM70 antibody"+"cancer"/"biomarker"进行精准查询。
The TMM70 antibody targets the TMM70 protein, a component of the mitochondrial translocase complex (TIM/TOM system) critical for importing nuclear-encoded proteins into mitochondria. TMM70. also known as TIM70 or TIMM70. resides in the mitochondrial inner membrane and facilitates the translocation of proteins with internal targeting signals. It plays a vital role in maintaining mitochondrial function, energy production, and cellular homeostasis.
Antibodies against TMM70 are widely used in research to study mitochondrial protein import mechanisms, mitochondrial dysfunction, and related pathologies such as neurodegenerative diseases (e.g., Parkinson’s), metabolic disorders, and cancer. Dysregulation of TMM70 has been linked to impaired mitochondrial dynamics, apoptosis, and oxidative stress.
The development of TMM70 antibodies has enabled advanced techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. These tools contribute to elucidating mitochondrial biology and exploring therapeutic strategies targeting mitochondrial pathways. However, specificity and cross-reactivity challenges require careful validation in experimental models. Overall, TMM70 antibodies serve as essential probes in both basic and translational research focused on mitochondrial health and disease.
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