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Rabbit Polyclonal MAP4K2/3 Antibody

  • 中文名： MAP4K2/3抗体
  • 别    名： Mitogen-activated protein kinase kinase kinase kinase 2; B lymphocyte serine/threonine-protein kinase; Germinal center kinase; GC kinase; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Rab8-interacting protein; Mitogen-activated protein ki
货号: IPDX23421
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesMitogen-activated protein kinase kinase kinase kinase 2; B lymphocyte serine/threonine-protein kinase; Germinal center kinase; GC kinase; MAPK/ERK kinase kinase kinase 2; MEK kinase kinase 2; MEKKK 2; Rab8-interacting protein; Mitogen-activated protein kinase kinase kinase kinase 3; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; MEKKK 3
Entrez GeneID5871/8491
WB Predicted band sizeCalculated MW: 92 kDa; Observed MW: 100 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenSynthesized peptide derived from human GCK/GLK. at AA range: 221-270
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于MAP4K2/3抗体的3篇参考文献(基于公开数据概括，非真实文献，仅供参考格式)：

1. **"MAP4K2 regulates T cell activation through CD28 signaling"**

- 作者：Smith A et al.

- 摘要：研究利用MAP4K2特异性抗体，通过Western blot和免疫共沉淀技术，揭示了MAP4K2在T细胞活化中通过调控CD28信号通路的分子机制。

2. **"MAP4K3 promotes cancer cell survival via AMPK pathway modulation"**

- 作者：Chen L et al.

- 摘要：通过免疫组化(使用MAP4K3抗体)分析肿瘤组织样本，发现MAP4K3高表达与AMPK活性抑制相关，可能通过抗凋亡作用促进癌症进展。

3. **"Development of a monoclonal antibody targeting MAP4K2 for autoimmune disease research"**

- 作者：Kim J et al.

- 摘要：报道了一种新型MAP4K2单克隆抗体的开发与验证，该抗体能特异性识别小鼠和人类MAP4K2蛋白，并成功用于流式细胞术检测免疫细胞中的表达水平。

如需真实文献，建议通过PubMed或Google Scholar搜索关键词：**MAP4K2 antibody** / **MAP4K3 antibody** 或相关别名(如GCK/GLK抗体)。

背景信息

MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2), also known as Germinal Center Kinase (GCK), and MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3), also referred to as Germinal Center Kinase-Like Kinase (GLK), are serine/threonine kinases belonging to the Ste20 family. These kinases act upstream of the MAPK (mitogen-activated protein kinase) signaling cascades, which regulate diverse cellular processes, including proliferation, differentiation, stress responses, and immune activation. MAP4K2 is implicated in T-cell receptor signaling, where it interacts with adaptor proteins like SLP-76 to modulate immune cell activation and inflammatory responses. MAP4K3 is involved in nutrient-sensing pathways, particularly through the mTORC1 (mechanistic target of rapamycin complex 1) signaling axis, influencing cell growth and autophagy under metabolic stress. Both kinases have been linked to pathological conditions; MAP4K2 overexpression correlates with autoimmune diseases and cancer progression, while MAP4K3 dysregulation is associated with metabolic disorders and oncogenesis. Antibodies targeting MAP4K2/3 are essential tools for studying their expression, phosphorylation status, and interactions in cellular pathways. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to elucidate their roles in disease mechanisms and therapeutic targeting. Validation of these antibodies includes specificity checks via knockout controls and functional assays to ensure accurate detection in experimental models.

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