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Rabbit Polyclonal KCTD7 Antibody

  • 中文名： KCTD7抗体
  • 别    名： BTB/POZ domain-containing protein KCTD7
货号: IPDX23415
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesSTHE; HKPX1
WB Predicted band size53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human GLRA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于KCTD7抗体的3篇参考文献，基于其研究背景和抗体应用场景的概括：

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1. **文献名称**：*Mutations in KCTD7 cause progressive epilepsy with cognitive disability but no sensory neuropathy*

**作者**：P. van Dijk et al. (2020)

**摘要**：本研究通过全外显子测序发现KCTD7基因突变与儿童进行性肌阵挛癫痫相关，并利用KCTD7抗体进行蛋白质印迹分析，显示突变导致蛋白表达显著降低，提示其功能缺失在神经退行中的作用。

2. **文献名称**：*KCTD7 regulates dendritic degradation via autophagy in neuronal development*

**作者**：S. Kim et al. (2018)

**摘要**：研究使用KCTD7特异性抗体在小鼠神经元中验证其蛋白定位，发现KCTD7通过调控自噬溶酶体通路参与树突修剪，抗体染色显示其在发育大脑皮层神经元中高表达。

3. **文献名称**：*KCTD7 interacts with Cullin3 to modulate substrate ubiquitination in lysosomal storage disorders*

**作者**：L. Wang et al. (2016)

**摘要**：该文献通过免疫共沉淀(使用KCTD7抗体)证明KCTD7与Cullin3形成E3泛素连接酶复合体，影响底物蛋白降解，为神经元蜡样脂褐质沉积症的分子机制提供新见解。

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以上文献均为虚构示例，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词“KCTD7 antibody”或“KCTD7 protein function”查询近年研究，重点关注疾病模型或分子机制类论文。

背景信息

The KCTD7 antibody is a tool used to study the KCTD7 protein, a member of the potassium channel tetramerization domain (KCTD)-containing protein family. KCTD7 is implicated in neuronal function and lysosomal regulation. Mutations in the KCTD7 gene are linked to autosomal recessive disorders, such as progressive myoclonic epilepsy and neuronal ceroid lipofuscinosis, characterized by neurodegeneration, seizures, and cognitive decline. The protein contains a conserved BTB/POZ domain, facilitating protein-protein interactions, and is thought to regulate ubiquitination pathways or ion channel activity. KCTD7 antibodies enable researchers to detect and quantify protein expression in tissues or cells, aiding investigations into its role in lysosomal storage disorders or epilepsy mechanisms. These antibodies are critical for immunohistochemistry, Western blotting, and immunofluorescence studies, helping map KCTD7 localization in the brain and other organs. Research using KCTD7 antibodies has revealed its presence in lysosomes and synaptic regions, suggesting involvement in synaptic vesicle recycling or autophagy. However, its precise molecular mechanisms remain unclear, necessitating further study. The development of specific, high-affinity KCTD7 antibodies has advanced diagnostic and therapeutic research, particularly in understanding how KCTD7 dysfunction contributes to pediatric neurodegenerative diseases. Ongoing studies aim to clarify its interactions with other proteins and potential as a biomarker or drug target.

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