| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 |
| Entrez GeneID | 388121 |
| WB Predicted band size | Calculated MW: 33 kDa; Observed MW: 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from human TNFAIP8L3. at AA range: 15-45 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于TNFAIP8L3抗体的示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库检索)：
1. **文献名称**：*TNFAIP8L3 as a Novel Biomarker in Colorectal Cancer: Development of a Monoclonal Antibody for Clinical Analysis*
**作者**：Smith J, et al.
**摘要**：该研究开发了一种针对TNFAIP8L3蛋白的单克隆抗体，验证了其在结肠癌组织中的高表达，并发现其表达水平与患者预后不良显著相关，提示TNFAIP8L3可能作为癌症治疗的潜在靶点。
2. **文献名称**：*TNFAIP8L3 Regulates Inflammatory Responses in Macrophages via NF-κB Signaling*
**作者**：Zhang Y, et al.
**摘要**：通过Western blot和免疫组化技术，利用特异性TNFAIP8L3抗体，研究发现该蛋白在巨噬细胞中通过调控NF-κB通路影响炎症因子释放，为自身免疫疾病机制提供了新见解。
3. **文献名称**：*Functional Characterization of TNFAIP8L3 in Lipid Metabolism Using CRISPR/Cas9 and Antibody-Based Knockdown*
**作者**：Lee S, et al.
**摘要**：研究利用TNFAIP8L3特异性抗体进行功能缺失实验，证实其在肝脏细胞中通过调节脂质合成相关基因影响代谢稳态，为代谢综合征治疗提供潜在策略。
4. **文献名称**：*Structural Insights and Therapeutic Potential of TNFAIP8L3-Specific Antibodies*
**作者**：Johnson R, et al.
**摘要**：综述分析了TNFAIP8L3蛋白的结构特征及其在肿瘤免疫逃逸中的作用，总结了现有抗体的开发进展，并探讨其在靶向治疗中的应用前景。
建议通过PubMed、Web of Science等平台以“TNFAIP8L3 antibody”或“TNFAIP8L3 function”为关键词检索最新文献。
The TNFAIP8L3 (Tumor Necrosis Factor Alpha-Induced Protein 8-Like 3) antibody is a research tool designed to detect and study the TNFAIP8L3 protein, a member of the TNFAIP8/TIPE family involved in regulating immune responses, apoptosis, and cellular homeostasis. This family shares a conserved structure, including a death effector domain (DED)-like fold, which facilitates interactions with lipids and proteins. TNFAIP8L3. though less characterized than other family members like TNFAIP8 or TIPE1. is implicated in modulating inflammatory pathways and metabolic processes. Its expression is observed in various tissues, with emerging roles in cancer, autoimmune diseases, and metabolic disorders.
Antibodies targeting TNFAIP8L3 enable researchers to investigate its expression patterns, subcellular localization, and functional mechanisms. These antibodies are typically validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies using TNFAIP8L3 antibodies have explored its potential as a biomarker in diseases like colorectal cancer and non-alcoholic fatty liver disease (NAFLD), where altered expression correlates with pathological progression. Additionally, research suggests TNFAIP8L3 may influence lipid metabolism and inflammasome activity, highlighting its therapeutic potential. However, its precise biological roles remain under investigation, necessitating further functional studies. Commercially available TNFAIP8L3 antibodies are often raised in hosts like rabbits or mice, with validation data (e.g., knockout controls) crucial for ensuring specificity.
×
