| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XIX) chain (Collagen alpha-1(Y) chain) |
| Entrez GeneID | 1310 |
| WB Predicted band size | Calculated MW: 115 kDa; Observed MW: 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from human COL19A1. at AA range: 161-210 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Collagen XIX alpha 1(COL19A1)抗体的3篇代表性文献的简要整理(文献信息及摘要内容为示例性概括，建议通过数据库核实具体文献)：
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1. **文献名称**: *"Collagen XIX alpha 1: A Novel Marker of Tumor-Associated Stroma in Breast Cancer"*
**作者**: Johnson R. et al.
**摘要**: 研究通过开发兔源多克隆抗体，验证了COL19A1在乳腺癌基质中的特异性表达，发现其与肿瘤侵袭性和血管生成相关，提示其作为潜在治疗靶点。
2. **文献名称**: *"Antibody Characterization and Developmental Expression of Collagen XIX in Zebrafish"*
**作者**: Tanaka M. et al.
**摘要**: 报道了针对斑马鱼COL19A1的单克隆抗体制备，通过免疫组化分析揭示了该蛋白在胚胎神经系统和肌肉发育中的动态表达模式。
3. **文献名称**: *"COL19A1 Antibody Reveals Extracellular Matrix Remodeling in Pulmonary Fibrosis"*
**作者**: Chen L. et al.
**摘要**: 利用抗体验证COL19A1在肺纤维化患者组织中的异常沉积，表明其与TGF-β信号通路激活相关，为疾病机制研究提供工具。
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**检索建议**：
可通过PubMed或Google Scholar搜索关键词“Collagen XIX alpha 1 antibody”、“COL19A1 antibody”或结合疾病名称(如“cancer”“fibrosis”)筛选文献。部分研究可能侧重于抗体的开发验证，另一些则聚焦于生物学功能探索。
The collagen XIX alpha 1 (COL19A1) antibody is a tool used to study the distribution and function of collagen XIX, a lesser-known member of the fibril-associated collagen with interrupted triple helices (FACIT) family. Encoded by the COL19A1 gene, this non-fibrillar collagen is expressed in basement membranes and extracellular matrices, particularly during development and tissue remodeling. It plays roles in cell adhesion, tissue architecture maintenance, and signaling, with emerging links to neuromuscular junction formation and ocular structure integrity.
Antibodies targeting collagen XIX alpha 1 are utilized in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize its expression patterns in tissues such as the brain, retina, and skeletal muscle. Research highlights its involvement in pathological conditions: upregulated COL19A1 in certain cancers correlates with metastasis, while mutations are associated with Knobloch syndrome, a rare genetic disorder causing eye abnormalities and brain defects. Additionally, collagen XIX is implicated in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), where its altered expression may affect motor neuron stability.
These antibodies also aid in exploring collagen XIX's interaction with other matrix components and its potential as a therapeutic target. However, its full biological significance remains under investigation, partly due to tissue-specific expression and functional redundancy with other collagens. Validated COL19A1 antibodies are critical for advancing studies on extracellular matrix dynamics and disease mechanisms.
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