| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UHX1; USP11 |
| Entrez GeneID | 8237 |
| WB Predicted band size | Calculated MW: 110 kDa; Observed MW: 110 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human USP11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于USP11抗体的3篇参考文献及其摘要概括：
1. **文献名称**：USP11 regulates DNA damage response through deubiquitinating RNF168
**作者**：Li F, et al.
**摘要**：该研究揭示USP11通过去泛素化修饰RNF168.调控DNA损伤修复过程。实验中利用特异性USP11抗体进行免疫印迹和免疫沉淀，证实其在维持基因组稳定性中的关键作用。
2. **文献名称**：USP11 promotes tumor progression via stabilization of Twist1 in colorectal cancer
**作者**：Zhang Y, et al.
**摘要**：文章发现USP11通过稳定转录因子Twist1促进结直肠癌转移。研究使用USP11抗体进行组织芯片分析，显示USP11高表达与患者预后不良相关。
3. **文献名称**：USP11 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1
**作者**：Wang Q, et al.
**摘要**：该研究证明USP11通过去泛素化Beclin-1调控自噬和抗病毒免疫反应。实验通过USP11抗体的基因敲低验证，揭示了其在天然免疫中的新机制。
(注：以上文献信息为示例，实际引用需以具体论文为准。)
USP11 (Ubiquitin-Specific Protease 11) is a deubiquitinating enzyme belonging to the USP family, which regulates protein stability, localization, and function by removing ubiquitin tags from target substrates. It plays critical roles in diverse cellular processes, including DNA damage repair, cell cycle regulation, epigenetic modulation, and immune response. USP11 is implicated in pathways such as TGF-β signaling, Wnt/β-catenin signaling, and the DNA damage response, often interacting with key proteins like BRCA2. RAD51. and IκBα. Dysregulation of USP11 has been linked to cancer progression, neurodegenerative diseases, and viral infections, making it a potential therapeutic target.
USP11 antibodies are essential tools for studying its expression, activity, and molecular interactions. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate USP11's subcellular localization, protein-protein interactions, and post-translational modifications. High-quality USP11 antibodies are validated for specificity, often through knockout cell lines or siRNA knockdown controls. Researchers also employ these antibodies to explore USP11's role in disease mechanisms, such as its oncogenic or tumor-suppressive effects in different cancer contexts. As USP11 gains attention in drug discovery, reliable antibodies remain crucial for both basic research and preclinical studies.
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