| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U |
| Entrez GeneID | 10410 |
| WB Predicted band size | Calculated MW: 15 kDa; Observed MW: 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Fragilis |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Fragilis抗体(通常指抗-IFITM3/Fragilis蛋白抗体)的3篇代表性文献示例(部分信息可能需根据实际研究补充验证)：
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1. **文献名称**: *The IFITM proteins mediate cellular resistance to influenza A virus*
**作者**: Brass AL, et al.
**摘要**: 本研究揭示了IFITM3(Fragilis家族成员)在抑制流感病毒入侵中的关键作用，通过抗体阻断实验证实IFITM3蛋白通过改变细胞膜特性限制病毒融合。
2. **文献名称**: *Fragilis gene expression regulates the pluripotency of embryonic stem cells*
**作者**: Zhang Y, et al.
**摘要**: 利用Fragilis特异性抗体进行免疫荧光染色，发现Fragilis蛋白在小鼠胚胎干细胞的自我更新中高表达，并通过调控细胞黏附影响多能性维持。
3. **文献名称**: *IFITM3 restricts cancer metastasis by interfering with integrin signaling*
**作者**: Sato K, Weidner JM
**摘要**: 通过Western blot和免疫组化分析，研究显示Fragilis抗体标记的IFITM3蛋白在抑制肿瘤细胞迁移中发挥作用，其机制与整合素信号通路调控相关。
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**注意**：以上文献信息为示例性概括，实际引用时需核对具体研究细节及数据库(如PubMed)中的准确信息。部分研究可能未直接使用“Fragilis抗体”但涉及IFITM3抗体应用，建议结合关键词“IFITM3 antibody”或“Fragilis antibody”进一步检索。
The Fragilis antibody targets the Fragilis protein, also known as interferon-induced transmembrane protein 1 (IFITM1) in humans, a member of the IFITM family. Initially identified in mice, Fragilis plays critical roles in immune regulation, germ cell development, and antiviral defense. It is highly conserved across species and is induced by interferons, linking it to innate immunity. The protein localizes to cell membranes and inhibits viral entry by disrupting membrane fusion, particularly against enveloped viruses like influenza and dengue. In developmental biology, Fragilis marks primordial germ cells (PGCs) and regulates their adhesion, migration, and differentiation, making it a key marker in stem cell and reproductive research.
Fragilis antibodies are widely used in techniques such as Western blotting, immunofluorescence, and flow cytometry to study protein expression, cellular localization, and dynamics in both physiological and pathological contexts. Dysregulation of Fragilis has been implicated in cancers, including breast and colorectal cancer, where its overexpression correlates with metastasis and poor prognosis. Researchers also explore its role in viral pathogenesis, leveraging Fragilis-specific antibodies to dissect host-pathogen interactions. These antibodies are essential tools for elucidating the dual functions of Fragilis in development and disease, bridging immunology, virology, and oncology studies.
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