| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ALPP; PLAP; Alkaline phosphatase; placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 |
| Entrez GeneID | 250 |
| WB Predicted band size | Calculated MW: 58 kDa; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Placental alkaline phosphatase (PLAP) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于胎盘碱性磷酸酶(Placental Alkaline Phosphatase, PLAP)抗体的参考文献摘要(注意：文献标题和作者为模拟示例，实际文献需通过学术数据库检索验证)：
1. **文献名称**: "Immunohistochemical Expression of Placental Alkaline Phosphatase in Germ Cell Tumors"
**作者**: Stickle et al. (2019)
**摘要**: 研究PLAP抗体在生殖细胞肿瘤中的免疫组化染色表现，证实其可作为精原细胞瘤和卵巢生殖细胞肿瘤的诊断标志物，并探讨抗体特异性与交叉反应性。
2. **文献名称**: "Placental Alkaline Phosphatase: A Review of Structure, Function, and Clinical Applications"
**作者**: Millan (1990)
**摘要**: 综述PLAP的生物学特性及其在妊娠和癌症中的表达，重点讨论多克隆/单克隆抗体的开发及其在组织病理学和血清学检测中的应用。
3. **文献名称**: "PLAP as a Biomarker in Breast Cancer: Insights from Antibody-Based Assays"
**作者**: Hui et al. (2015)
**摘要**: 通过PLAP抗体检测乳腺癌患者组织样本，发现其高表达与肿瘤侵袭性相关，提示PLAP可能作为预后评估工具。
4. **文献名称**: "Development of a Monoclonal Antibody Against PLAP for Early Pregnancy Detection"
**作者**: Kawai et al. (2008)
**摘要**: 报道一种高亲和力PLAP单克隆抗体的开发，验证其在妊娠早期血清检测中的敏感性和特异性，并应用于临床诊断试剂盒。
**建议**：通过PubMed或Google Scholar检索真实文献时，可尝试关键词：*"Placental Alkaline Phosphatase antibody" + diagnostic/cancer/pregnancy*，并筛选近5-10年研究以获取最新进展。
Placental alkaline phosphatase (PLAP) is a tissue-specific isoenzyme belonging to the alkaline phosphatase family, primarily expressed in the placenta during pregnancy. It plays a role in nutrient transport and cellular development. While PLAP is normally restricted to placental trophoblasts, its ectopic expression is observed in various malignancies, particularly germ cell tumors (e.g., seminomas, dysgerminomas) and certain epithelial cancers (e.g., ovarian, lung, and gastrointestinal cancers). This oncofetal characteristic makes PLAP a valuable biomarker in diagnostic pathology.
Antibodies targeting PLAP are widely used in immunohistochemistry (IHC) to identify PLAP-expressing tumor cells, aiding in cancer classification and differential diagnosis. However, interpretation requires caution, as low PLAP levels may occur in normal tissues (e.g., cervix, lung) and non-germ cell neoplasms. Clinically, PLAP antibody-based assays also assist in monitoring disease recurrence or residual tumors post-treatment. Beyond oncology, PLAP antibodies contribute to reproductive biology research, exploring placental function and gestational disorders. Recent studies investigate its potential role in stem cell regulation and cancer stem cell targeting. Despite advances, PLAP's exact biological mechanisms in both physiological and pathological contexts remain partially understood, underscoring the continued relevance of PLAP antibodies in research and diagnostics.
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