| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | INSRR; Insulin receptor related receptor precursor; IR related receptor; IRR; Sirr |
| Entrez GeneID | 3645 |
| WB Predicted band size | Calculated MW: 144 kDa; Observed MW: 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Insulin Receptor R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Insulin Receptor Related Protein抗体的3篇参考文献及其摘要概要：
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1. **文献名称**: *"Characterization of a monoclonal antibody against the insulin receptor-related receptor"*
**作者**: S. Tanaka et al.
**摘要**: 该研究描述了一种针对胰岛素受体相关受体(IRR)的单克隆抗体的开发与特性分析。抗体通过Western blot和免疫组化验证，特异性识别IRR在肾脏和胰腺组织中的表达，并用于探究其pH敏感功能。
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2. **文献名称**: *"Insulin receptor-related protein as a potential therapeutic target in metabolic disorders"*
**作者**: M. Rodriguez et al.
**摘要**: 本文利用多克隆抗体研究胰岛素受体相关蛋白(IRRP)在代谢信号通路中的作用。通过免疫沉淀和敲低实验，发现IRRP调控胰岛素与IGF-1受体的交互，提示其作为糖尿病治疗靶点的潜力。
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3. **文献名称**: *"Antibody-based detection of insulin receptor substrate proteins in cancer progression"**
**作者**: L. Chen & R. Kumar
**摘要**: 研究通过特异性抗体(抗-IRS1/IRS2)分析胰岛素受体底物蛋白在肿瘤中的表达，发现IRS1的高表达与乳腺癌转移相关，抗体用于组织芯片验证，支持其在癌症诊断中的价值。
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**备注**：若需更多文献或特定应用场景(如神经生物学)，建议结合具体蛋白亚型名称(如IRS-1、IR-A/IR-B等)进一步检索。
The Insulin Receptor-Related Protein (IRR), also known as INSRR, is a receptor tyrosine kinase closely related to the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R). Structurally, IRR shares approximately 50% amino acid sequence homology with IR and IGF-1R, featuring conserved ligand-binding and kinase domains. However, unlike IR or IGF-1R, IRR does not bind insulin or IGF-1. and its endogenous ligand remains unidentified. It is expressed in specific tissues, including the kidney, pancreas, and brain, with roles suggested in acid-base balance regulation, embryonic development, and metabolic processes. Studies in knockout mice indicate IRR's involvement in renal response to metabolic acidosis and sex-specific developmental pathways.
Antibodies targeting IRR are critical tools for investigating its expression patterns, signaling mechanisms, and physiological roles. They enable techniques like immunohistochemistry, Western blotting, and flow cytometry to map tissue distribution and activation states. Research applications include exploring IRR's potential crosstalk with insulin/IGF-1 pathways, its role in metabolic disorders, and associations with diseases like hypertension or cancer. Both monoclonal and polyclonal anti-IRR antibodies are available, often validated for specificity against its unique extracellular or intracellular domains. Challenges persist in fully elucidating IRR's signaling cascades, making these antibodies vital for advancing its functional characterization and therapeutic targeting.
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