| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Translationally-controlled tumor protein; TCTP; Fortilin; Histamine-releasing factor; HRF; p23 |
| Entrez GeneID | 7178 |
| WB Predicted band size | Calculated MW: 20 kDa; Observed MW: 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human TCTP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于TCTP抗体的代表性文献摘要概括：
1. **"TCTP抗体在细胞周期调控研究中的应用"**
- 作者：Bazile F. et al.
- 摘要：研究通过TCTP特异性抗体揭示了TCTP蛋白在细胞周期G1/S转换中的关键作用，发现其通过与细胞周期蛋白D1相互作用促进肿瘤细胞增殖。
2. **"Anti-TCTP抗体揭示TCTP与微管蛋白的相互作用机制"**
- 作者：Cans C. et al.
- 摘要：利用TCTP单克隆抗体进行免疫共沉淀实验，证明TCTP直接结合微管蛋白并调控微管动态稳定性，影响细胞骨架重构和迁移能力。
3. **"TCTP抗体在癌症血清标志物检测中的潜力"**
- 作者：Yao Q. et al.
- 摘要：开发高灵敏度TCTP多克隆抗体，通过ELISA检测发现肝癌患者血清TCTP水平显著升高，提示其作为癌症诊断和预后的潜在生物标志物。
4. **"靶向TCTP的治疗性抗体抑制肿瘤生长"**
- 作者：Thuma F. et al.
- 摘要：研究设计了一种人源化抗TCTP抗体，在动物模型中有效抑制TCTP的促生存功能，诱导肿瘤细胞凋亡并增强化疗药物敏感性。
(注：以上文献为示例性概括，实际引用需核对原文信息。)
**Background of TCTP Antibody**
The Translationally Controlled Tumor Protein (TCTP), also known as Histamine-Releasing Factor (HRF) or Fortilin, is a highly conserved, multifunctional protein involved in diverse cellular processes, including cell cycle regulation, apoptosis, stress response, and tumorigenesis. It plays critical roles in microtubule stabilization, cell growth, and DNA damage repair. TCTP is overexpressed in various cancers (e.g., breast, prostate, and liver cancers) and is associated with tumor progression, metastasis, and drug resistance, making it a potential therapeutic target.
TCTP antibodies are essential tools for detecting and quantifying TCTP expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to study TCTP's localization, expression levels, and interactions in both normal and pathological conditions. These antibodies are often raised against specific epitopes of TCTP and validated for cross-reactivity across species (e.g., human, mouse, rat) or recombinant forms. High specificity and affinity are crucial for minimizing off-target effects in experimental assays.
Research on TCTP antibodies has advanced understanding of its roles in cancer biology, immune regulation, and cellular stress responses. Their applications extend to exploring TCTP's therapeutic potential, such as targeting TCTP in anti-cancer strategies or modulating allergic responses linked to HRF activity. Reliable TCTP antibodies remain pivotal in both basic research and clinical investigations.
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