| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP |
| Entrez GeneID | 6616 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SNAP25 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SNAP25抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *SNAP-25 is a promising novel cerebrospinal fluid biomarker for synaptic degeneration in Alzheimer’s disease*
**作者**: Brinkmalm G, et al.
**摘要**: 该研究提出SNAP25可作为阿尔茨海默病(AD)中突触退化的生物标志物。通过检测脑脊液中的SNAP25片段，发现AD患者中SNAP25水平显著升高，提示其与突触功能障碍相关。
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2. **文献名称**: *Autoantibodies to the beta cell surface antigen SNAP-25 are associated with rapid progression to type 1 diabetes*
**作者**: Wenzlau JM, et al.
**摘要**: 研究发现SNAP25自身抗体在1型糖尿病早期患者中高度表达，可作为疾病进展的预测指标，揭示了SNAP25在自身免疫性β细胞破坏中的作用。
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3. **文献名称**: *Paraneoplastic antibodies against SNAP-25 in a patient with small cell lung carcinoma and limbic encephalitis*
**作者**: Sabater L, et al.
**摘要**: 报道一例小细胞肺癌合并边缘性脑炎患者体内存在针对SNAP25的副肿瘤抗体，提示SNAP25抗体可能参与神经副肿瘤综合征的病理机制，并具有潜在诊断价值。
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4. **文献名称**: *SNAP-25 regulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization*
**作者**: Pozzi D, et al.
**摘要**: 通过SNAP25抗体干扰实验，揭示SNAP25通过调节钙离子动态平衡，影响GABA能和谷氨酸能神经元对去极化的反应差异，阐明了其在突触传递中的功能特异性。
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以上文献涵盖了SNAP25抗体在神经退行性疾病、自身免疫疾病、副肿瘤综合征及基础神经科学中的应用研究。
SNAP25 (Synaptosomal-associated protein 25 kDa) is a key component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, essential for synaptic vesicle fusion and neurotransmitter release in neurons. This membrane-associated protein interacts with syntaxin and synaptobrevin (VAMP) to mediate exocytosis. Antibodies targeting SNAP25 are widely used as research tools to study its expression, localization, and function in neuronal communication, endocrine secretion, and cellular trafficking pathways.
SNAP25 exists as two alternatively spliced isoforms (SNAP25a and SNAP25b) with distinct roles in secretory cells. Its dysregulation has been implicated in neurological disorders such as schizophrenia, ADHD, and Alzheimer's disease, as well as autoimmune conditions like botulism. Anti-SNAP25 antibodies enable detection through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Some studies explore SNAP25 autoantibodies as potential biomarkers for paraneoplastic neurological syndromes and psychiatric conditions. Recent research also investigates SNAP25's involvement in non-neuronal systems, including pancreatic beta cells and cancer biology. These antibodies continue to advance our understanding of vesicle dynamics and their pathophysiological implications across multiple disciplines.
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