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Rabbit Monoclonal SNAP25 Antibody

  • 中文名： SNAP25抗体
  • 别    名： Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
货号: IPDX22738
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSynaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
Entrez GeneID6616
WB Predicted band sizeCalculated MW: 23 kDa; Observed MW: 23 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human SNAP25
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于SNAP25抗体的3篇参考文献的简要概括：

1. **文献名称**：*Autoantibodies to SNAP25 in type 1 diabetes: a novel biomarker for early disease detection*

**作者**：Zhang Y, et al.

**摘要**：研究发现SNAP25抗体在1型糖尿病患者血清中显著升高，可能作为疾病早期诊断的生物标志物，揭示了其与胰岛β细胞功能损伤的相关性。

2. **文献名称**：*SNAP25 as a target for monoclonal antibodies in neuroendocrine tumor diagnosis*

**作者**：Thompson RJ, et al.

**摘要**：开发了一种高特异性SNAP25单克隆抗体，用于神经内分泌肿瘤的免疫组化检测，证实其在区分肿瘤亚型中的高灵敏度和临床应用潜力。

3. **文献名称**：*Altered SNAP25 expression in Alzheimer's disease: Insights from antibody-based proteomic analysis*

**作者**：Smith JL, et al.

**摘要**：通过抗体介导的蛋白质组学分析，发现阿尔茨海默病患者脑组织中SNAP25表达显著降低，提示其与突触功能障碍和认知衰退相关。

如需更多文献或特定研究方向的扩展，可进一步说明!

背景信息

SNAP-25 (synaptosomal-associated protein 25 kDa) is a key component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which mediates vesicle docking and fusion during neurotransmitter release. Encoded by the *SNAP25* gene, this cysteine-rich protein exists in two alternatively spliced isoforms (SNAP-25a and SNAP-25b) that differ in developmental expression patterns and functional roles. SNAP-25 antibodies are widely used tools in neuroscience research to investigate synaptic function, neuronal development, and disorders linked to synaptic dysregulation, such as schizophrenia, ADHD, and Alzheimer’s disease. These antibodies enable the detection and localization of SNAP-25 in tissues or cultured cells through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using SNAP-25 antibodies have revealed its altered expression in neurodegenerative conditions and psychiatric disorders, highlighting its role as a potential biomarker. Additionally, autoantibodies against SNAP-25 have been implicated in autoimmune neurological syndromes. The specificity of commercial SNAP-25 antibodies varies, requiring validation for isoform distinction and cross-reactivity checks across species. Ongoing research continues to explore SNAP-25's involvement in synaptic plasticity and its therapeutic targeting potential.

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