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Rabbit Monoclonal TRIM56 Antibody

  • 中文名： TRIM56抗体
  • 别    名： RING finger protein 109; RNF109
货号: IPDX22731
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesRING finger protein 109; RNF109
Entrez GeneID81844
WB Predicted band sizeCalculated MW: 81 kDa; Observed MW: 81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human TRIM56
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于TRIM56抗体的虚构参考文献示例(仅供格式参考，非真实文献)：

1. **文献名称**: "TRIM56-mediated antiviral response against RNA viruses through RIG-I signaling"

**作者**: Li X, Chen Z, et al.

**摘要**: 本研究利用TRIM56特异性抗体，揭示了TRIM56通过增强RIG-I的泛素化修饰，激活I型干扰素通路，从而抑制RNA病毒(如HCV)复制的分子机制。

2. **文献名称**: "Characterization of TRIM56 as a DNA virus restriction factor in human cells"

**作者**: Wang Y, Deng T, et al.

**摘要**: 通过免疫沉淀(IP)和Western blot技术结合TRIM56抗体，证实TRIM56可直接结合HSV-1病毒DNA，并促进STING依赖的先天免疫应答，抑制疱疹病毒复制。

3. **文献名称**: "The E3 ligase activity of TRIM56 regulates cellular apoptosis via modulating p53 stability"

**作者**: Zhang R, Liu H, et al.

**摘要**: 利用TRIM56抗体进行共聚焦显微镜观察，发现TRIM56通过其E3泛素连接酶活性调控p53蛋白稳定性，影响DNA损伤诱导的细胞凋亡过程。

4. **文献名称**: "TRIM56 antibody-based detection in autoimmune disorders: Correlation with interferon signatures"

**作者**: Kumar S, Lee J, et al.

**摘要**: 研究使用TRIM56抗体分析患者血清蛋白水平，发现TRIM56在系统性红斑狼疮(SLE)中异常高表达，并与干扰素通路的过度激活相关。

**注意**：以上文献为示例性质，实际文献需通过PubMed、Google Scholar等平台检索关键词“TRIM56 antibody”或“TRIM56 function”获取。

背景信息

The TRIM56 antibody is a research tool used to detect and study TRIM56 (Tripartite Motif-containing protein 56), a member of the TRIM protein family involved in innate immunity, antiviral defense, and cellular regulation. TRIM56 contains characteristic RING, B-box, and coiled-coil domains, enabling its function as an E3 ubiquitin ligase that modifies target proteins via ubiquitination. Research highlights its role in modulating immune responses, particularly against RNA viruses (e.g., influenza, dengue) and DNA viruses (e.g., herpesviruses), by enhancing interferon signaling or directly disrupting viral replication. TRIM56 antibodies are typically developed in hosts like rabbits or mice, validated for specificity through techniques such as Western blotting, immunofluorescence, or immunoprecipitation. These antibodies aid in exploring TRIM56’s expression patterns, subcellular localization, and interactions with viral or host proteins. Studies using TRIM56 antibodies have also linked the protein to broader cellular processes, including DNA damage repair and apoptosis. Its dysregulation is implicated in certain cancers and infectious diseases, making it a potential therapeutic target. Researchers rely on high-quality TRIM56 antibodies to dissect its mechanisms in health and disease, contributing to advances in virology, immunology, and molecular biology.

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