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Rabbit Monoclonal EYA2 Antibody

  • 中文名: EYA2抗体
  • 别    名: EAB1
货号: IPDX22356
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEAB1
Entrez GeneID2139
WB Predicted band sizeCalculated MW: 59 kDa; Observed MW: 59 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthetic peptide of human EYA2
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是3篇与EYA2抗体相关的模拟参考文献示例(注:以下内容为虚构示例,实际文献需通过学术数据库查询):

1. **文献名称**: "EYA2 Phosphatase Activity Promotes Tumor Angiogenesis via HIF-1α Stabilization in Breast Cancer"

**作者**: Zhang L, et al.

**摘要**: 本研究利用特异性EYA2抗体进行免疫沉淀及免疫组化分析,发现EYA2通过去磷酸化HIF-1α增强其稳定性,促进乳腺癌血管生成,提示EYA2作为潜在治疗靶点。

2. **文献名称**: "Developmental Expression and Functional Screening of EYA2 in Zebrafish Embryogenesis"

**作者**: Smith JR, et al.

**摘要**: 通过Western blot和免疫荧光技术结合EYA2抗体,证实EYA2在斑马鱼胚胎神经管发育中调控细胞迁移,其缺失导致形态发育异常。

3. **文献名称**: "EYA2 Co-Amplification with HER2 in Gastric Cancer Correlates with Poor Prognosis"

**作者**: Tanaka K, et al.

**摘要**: 使用抗EYA2抗体对胃癌组织芯片进行染色,发现EYA2与HER2基因共扩增,且高表达患者总生存期显著缩短,提示其作为预后生物标志物的潜力。

如需真实文献,建议在PubMed或Google Scholar中搜索关键词“EYA2 antibody”、“EYA2 function”或“EYA2 cancer”。

背景信息

The EYA2 antibody is a tool used to study the EYA2 protein, a member of the Eyes Absent (EYA) family of transcriptional coactivators and phosphatases. EYA proteins, including EYA1-4. play critical roles in embryonic development, particularly in organogenesis, cell migration, and DNA repair. EYA2 is notable for its dual enzymatic functions: its N-terminal domain facilitates transcriptional activation by interacting with transcription factors like SIX1. while its C-terminal region exhibits tyrosine phosphatase activity. Dysregulation of EYA2 has been implicated in cancer progression, including breast, ovarian, and colorectal cancers, where it promotes metastasis, chemoresistance, and cell survival via pathways like TGF-β and Hippo signaling.

The EYA2 antibody is essential for detecting EYA2 expression and localization in tissues or cell lines. It is widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate EYA2’s role in disease mechanisms. Studies using this antibody have revealed elevated EYA2 levels in certain tumors, correlating with poor patient prognosis. Additionally, EYA2’s involvement in DNA damage repair and immune modulation makes it a potential therapeutic target. Researchers rely on validated EYA2 antibodies to ensure specificity, as cross-reactivity with other EYA family members can complicate interpretations. Overall, the EYA2 antibody serves as a key reagent in both basic research and translational studies exploring developmental biology and oncology.

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