| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ADE2; AIRC; PAIS; ADE2H1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PAICS |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDK16抗体的3篇参考文献示例(注：以下为模拟内容，实际文献可能需要通过学术数据库验证):
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1. **文献名称**：*"A monoclonal antibody targeting CDK16 inhibits tumor growth in preclinical models of colorectal cancer"*
**作者**：Li Y, et al.
**摘要**：研究团队开发了一种靶向CDK16的单克隆抗体，证实其通过阻断CDK16与cyclin Y的相互作用抑制结直肠癌细胞增殖，并在小鼠模型中显著减少肿瘤体积。
2. **文献名称**：*"Development and validation of a phospho-specific antibody for CDK16 kinase activity detection"*
**作者**：Wang X, et al.
**摘要**：本文报道了一种特异性识别CDK16磷酸化形式(Thr168)的多克隆抗体的开发，该抗体被用于评估CDK16在细胞周期中的激活状态，并揭示其在肺癌中的异常激活。
3. **文献名称**：*"CDK16 expression in glioblastoma: Insights from a novel immunohistochemical antibody and clinical correlations"*
**作者**：Garcia-Rocha M, et al.
**摘要**：通过新型抗CDK16抗体的免疫组化分析，研究发现CDK16在胶质母细胞瘤中高表达，且与患者生存期缩短显著相关，提示其作为潜在治疗靶点。
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如需实际文献，建议检索PubMed或Google Scholar，使用关键词“CDK16 antibody”、“anti-CDK16”或“CDK16 kinase inhibitor”进一步筛选。
**Background of CDK16 Antibody**
CDK16 (Cyclin-Dependent Kinase 16), also known as PCTAIRE1. is a member of the CDK family, which plays critical roles in regulating cell cycle progression, transcription, and neuronal functions. Unlike canonical CDKs (e.g., CDK1. CDK2), CDK16 requires binding to cyclin Y or cyclin A for activation and exhibits unique expression patterns, predominantly in the testes, brain, and certain cancer cells. Its involvement in cell division, differentiation, and vesicular trafficking underscores its importance in development and disease.
CDK16 has gained attention for its oncogenic potential. Overexpression or dysregulation of CDK16 is linked to cancers, including prostate, liver, and breast cancers, where it promotes tumor growth, metastasis, and therapy resistance. Studies also suggest roles in neurodevelopment, with implications in disorders like Alzheimer’s disease.
CDK16 antibodies are essential tools for detecting and studying the protein’s expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore CDK16’s role in physiological and pathological contexts. High-quality CDK16 antibodies are validated for specificity, often through knockout controls, to ensure accurate detection and minimize cross-reactivity with other CDKs.
Research utilizing CDK16 antibodies continues to unveil its regulatory mechanisms, therapeutic potential, and utility as a biomarker, driving interest in targeting CDK16 for cancer treatment and neurological disease intervention.
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