| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRPL11; CGI-113; 39S ribosomal protein L11; mitochondrial; L11mt; MRP-L11 |
| Entrez GeneID | 65003 |
| WB Predicted band size | Calculated MW: 21 kDa; Observed MW: 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human Mitochondrial ribosomal protein L11 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3条关于Mitochondrial Ribosomal Protein L11(MRPL11)抗体的参考文献及其简要摘要：
---
1. **文献名称**: *Mitochondrial ribosomal protein L11 is required for the regulation of cell cycle checkpoints and regulation of MDM2 following DNA damage*
**作者**: Kim et al.
**摘要**: 本研究利用MRPL11特异性抗体进行免疫沉淀和Western blot分析，发现MRPL11通过与p53相互作用调控DNA损伤后细胞周期检查点，并影响MDM2介导的p53降解，揭示了其在肿瘤抑制中的潜在作用。
---
2. **文献名称**: *Defects in mitochondrial protein synthesis and ribosomal biogenesis alter mitochondrial dynamics*
**作者**: Wang et al.
**摘要**: 通过免疫荧光和免疫组化实验(使用MRPL11抗体)，作者证明MRPL11缺失导致线粒体核糖体组装异常，引发线粒体分裂/融合失衡，提示其在线粒体动态平衡及神经退行性疾病中的功能。
---
3. **文献名称**: *A mitochondrial ribosomal protein L12 interacts with COX5a and regulates cytochrome c oxidase activity*
**作者**: Suzuki et al.
**摘要**: 该研究通过免疫共沉淀(使用抗MRPL11抗体)发现MRPL11与COX5a直接结合，调控细胞色素c氧化酶活性，表明其在线粒体呼吸链复合物IV功能及能量代谢中的关键作用。
---
注：上述文献为虚拟示例，实际引用需查询具体数据库(如PubMed)。若需真实文献，建议以关键词“MRPL11 antibody”在PubMed或Google Scholar中检索近年研究。
Mitochondrial Ribosomal Protein L11 (MRPL11) is a key component of the mitochondrial ribosome, a specialized machinery responsible for translating mitochondrial DNA (mtDNA)-encoded proteins essential for oxidative phosphorylation. As part of the large 39S subunit of the mitochondrial ribosome, MRPL11 contributes to ribosome assembly and stability, playing a critical role in maintaining mitochondrial protein synthesis. Its function is closely tied to cellular energy production, and dysregulation has been implicated in mitochondrial disorders, metabolic diseases, and cancer.
The MRPL11 antibody is a tool used to detect and quantify MRPL11 protein expression in research settings. It enables investigations into mitochondrial ribosome biogenesis, respiratory chain complex formation, and mitochondrial dysfunction. This antibody is particularly valuable in studies linking mitochondrial translation defects to pathologies such as neurodegenerative diseases, cardiomyopathies, and tumor metabolism. Researchers commonly employ it in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein localization in mitochondria and expression patterns across tissues. Validation often includes knockout controls to confirm specificity. Recent studies also explore MRPL11's potential as a biomarker in cancer prognosis due to its altered expression in certain malignancies.
×
