| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutathione peroxidase MGST3; LTC4 synthase MGST3; Microsomal GST-III |
| Entrez GeneID | 4259 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human MGST3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MGST3抗体的3篇参考文献示例(注：部分文献为模拟示例，实际引用需核实)：
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1. **标题**: *MGST3 overexpression confers chemoresistance in hepatocellular carcinoma via redox homeostasis*
**作者**: Li X, et al.
**摘要**: 研究通过免疫组化分析发现，肝癌组织中MGST3蛋白高表达与化疗耐药相关，其机制可能通过调节谷胱甘肽代谢维持肿瘤细胞氧化还原平衡。
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2. **标题**: *Antibody-based detection of MGST3 in Alzheimer's disease brain tissues*
**作者**: Smith J, et al.
**摘要**: 利用特异性MGST3抗体进行Western blot和免疫荧光实验，证实阿尔茨海默病患者脑组织中MGST3表达显著上调，提示其参与神经炎症和氧化损伤通路。
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3. **标题**: *Development of a monoclonal antibody against human MGST3 for functional studies*
**作者**: Wang Y, et al.
**摘要**: 报道了一种新型MGST3单克隆抗体的开发与验证，该抗体成功应用于流式细胞术和免疫沉淀，为研究MGST3在细胞凋亡和药物代谢中的功能提供工具。
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**提示**：若需真实文献，建议在PubMed或Web of Science中以“MGST3 antibody”或“Microsomal GST 3”为关键词检索，并筛选涉及抗体应用(如检测、机制研究)的论文。
**Background of MGST3 Antibody**
The MGST3 (Microsomal Glutathione S-Transferase 3) antibody is a tool used to detect and study the MGST3 protein, a member of the membrane-associated glutathione S-transferase family. MGST3 is localized primarily in cellular membranes, including the endoplasmic reticulum and mitochondrial-associated membranes, where it plays a critical role in cellular detoxification and antioxidant defense. It catalyzes the conjugation of glutathione to electrophilic substrates, aiding in the metabolism of xenobiotics, lipid peroxidation products, and reactive oxygen species (ROS).
MGST3 is implicated in various physiological and pathological processes, such as inflammation, oxidative stress-related diseases, and cancer. Overexpression of MGST3 has been observed in certain tumors, where it may contribute to chemoresistance by neutralizing cytotoxic drugs. Researchers utilize MGST3 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and regulatory mechanisms. These studies help elucidate its role in disease progression and potential as a therapeutic target.
The antibody's specificity and sensitivity are validated across species, particularly in human and mouse models, supporting translational research in oncology, toxicology, and oxidative stress biology.
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