| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog |
| Entrez GeneID | 7514 |
| WB Predicted band size | Calculated MW: 123 kDa; Observed MW: 123 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human CRM1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于CRM1抗体的3篇参考文献示例(部分信息为虚构示例，仅用于演示格式)：
1. **文献名称**：*Development of a High-Affinity Anti-CRM1 Antibody for Studying Nuclear Export Mechanisms*
**作者**：Tanaka A. et al.
**摘要**：本研究报道了一种新型单克隆抗体的开发，该抗体特异性识别CRM1/XPO1蛋白的C端结构域。通过免疫荧光和Co-IP验证，证明其可用于检测CRM1在肿瘤细胞中的亚细胞定位及与底物蛋白的相互作用。
2. **文献名称**：*CRM1 Inhibition by Monoclonal Antibody Sensitizes Drug-Resistant Leukemia Cells to Chemotherapy*
**作者**：Zhang L. et al.
**摘要**：团队开发了一种阻断CRM1核输出功能的抗体，证明其能有效抑制慢性粒细胞白血病模型中癌蛋白(如BCR-ABL)的核质转运，并与伊马替尼产生协同治疗效果。
3. **文献名称**：*Comparative Analysis of Commercial CRM1 Antibodies in Diagnostic Applications*
**作者**：Müller S. & Schmidt B.
**摘要**：系统性评估了市售CRM1抗体的灵敏度与特异性，发现克隆H3抗体在福尔马林固定石蜡包埋组织中表现最优，为癌症病理诊断中CRM1过表达的检测提供了标准化建议。
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**提示**：实际检索时建议通过PubMed等数据库搜索关键词(如"CRM1 antibody"、"XPO1 antibody")，筛选实验研究类论文，重点关注抗体的开发、验证或应用研究。经典文献可参考2000年代初期关于CRM1功能鉴定的研究。
CRM1 (Chromosome Region Maintenance 1), also known as Exportin-1 (XPO1), is a key nuclear export receptor responsible for transporting proteins and RNA molecules from the nucleus to the cytoplasm. It plays a critical role in regulating nucleocytoplasmic transport, cell cycle progression, and stress responses. Dysregulation of CRM1 is linked to cancer development, viral infections, and autoimmune diseases, as it often leads to aberrant localization of tumor suppressors (e.g., p53. FOXO) or oncoproteins.
CRM1 antibodies are essential tools for studying its expression, localization, and functional interactions in cellular pathways. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate CRM1 overexpression in malignancies or its role in viral replication cycles. Additionally, these antibodies aid in evaluating the efficacy of CRM1-targeted therapies, such as selective inhibitors of nuclear export (SINE compounds), which block CRM1-mediated transport and induce cancer cell apoptosis.
The development of CRM1 antibodies has advanced cancer research and drug discovery, particularly in understanding resistance mechanisms and optimizing therapeutic strategies. Their clinical relevance extends to prognostic biomarker studies and monitoring treatment responses in CRM1-dependent diseases.
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