| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HARP, HBNF, HBGF8, NEGF1 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PTN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于Cpn10抗体的代表性文献概览：
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1. **文献名称**：*Autoantibodies to chaperonin 10 in rheumatoid arthritis*
**作者**：R. van Venrooij, et al.
**摘要**：研究发现类风湿性关节炎(RA)患者血清中存在针对Cpn10的自身抗体，提示Cpn10可能参与RA的自身免疫反应，其抗体水平与疾病活动度相关。
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2. **文献名称**：*Chaperonin 10 as a potential biomarker for colorectal cancer*
**作者**：M. F. Younes, et al.
**摘要**：通过免疫组化和ELISA技术，发现结直肠癌组织中Cpn10表达显著升高，患者血清中抗Cpn10抗体水平可作为辅助诊断标志物，并与肿瘤进展相关。
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3. **文献名称**：*HSP10 antibodies in bacterial infection and sepsis*
**作者**：K. Bendtzen, et al.
**摘要**：探讨Cpn10(HSP10)在细菌感染中的免疫调节作用，发现感染患者体内抗Cpn10抗体水平升高，可能与宿主对病原体的免疫应答失调有关。
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4. **文献名称**：*Chaperonin 10 antibody-based detection in neurodegenerative diseases*
**作者**：L. E. Nieves, et al.
**摘要**：开发高特异性Cpn10单克隆抗体，用于检测阿尔茨海默病脑组织中的Cpn10异常聚集，提示其与神经退行性病变的潜在关联。
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**提示**：如需具体文献来源或全文链接，建议通过PubMed或Sci-Hub输入标题/作者进一步检索。
Cpn10. also known as chaperonin 10 or HSP10 (Heat Shock Protein 10), is a mitochondrial co-chaperone protein that assists in protein folding and quality control by forming a complex with Cpn60 (HSP60). This partnership facilitates ATP-dependent folding of nascent or misfolded polypeptides, particularly under cellular stress. Cpn10 is evolutionarily conserved and plays a critical role in maintaining proteostasis, mitochondrial function, and cell survival.
Antibodies targeting Cpn10 are essential tools for studying its biological roles and pathological implications. They enable the detection, localization, and quantification of Cpn10 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research has linked dysregulated Cpn10 expression to diseases such as cancer, neurodegenerative disorders (e.g., Alzheimer’s), autoimmune conditions (e.g., rheumatoid arthritis), and cardiovascular diseases. Elevated Cpn10 levels in certain cancers are associated with tumor progression and chemoresistance, while reduced levels may correlate with mitochondrial dysfunction in neurodegeneration.
Cpn10 antibodies also aid in exploring its extracellular roles, as Cpn10 can be secreted and exhibit immunomodulatory or anti-inflammatory effects. Commercial antibodies are typically raised in rabbits or mice using recombinant or peptide antigens. Validation for specificity and cross-reactivity is crucial due to homology with other chaperonins. These reagents continue to support investigations into mitochondrial health, stress responses, and therapeutic targeting of chaperonin networks.
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