关键信息
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基因名
ASC1
- 应用
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别名
SLC7A10; Solute Carrier Family 7 Member 10,Neutral Amino Acid Transporter,y+ System
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NS82
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表达区间
Cys475~Gln523
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分子量
40kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ASC1, or Apoptosis-associated speck-like protein containing a CARD, is a crucial component of various signaling pathways involved in cellular processes such as apoptosis, inflammation, and immune response. As a part of the innate immune system, ASC1 plays a pivotal role in the assembly of multi-protein complexes known as inflammasomes, which are integral for the activation of caspase-1 and the subsequent secretion of pro-inflammatory cytokines like IL-1β and IL-18. Continued research into ASC1 and its roles in disease mechanisms, particularly in chronic inflammatory conditions and cancers, emphasizes the importance of understanding its structure and function at the molecular level. Recombinant ASC1 protein has been generated to facilitate studies regarding its interactions with other proteins and its influence on cellular pathways. This production of ASC1 in heterologous systems has enabled researchers to investigate its potential as a therapeutic target, offering insights into how modulation of ASC1 functions may alter inflammatory responses or apoptotic processes. Understanding ASC1's role in disease could lead to novel approaches for treating a range of conditions linked to dysregulated apoptosis or inflammation. Thus, the study of ASC1 recombinant protein not only furthers basic scientific knowledge but also holds promise for the development of future therapeutic strategies.
