关键信息
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基因名
DOG1
- 应用
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别名
DOG1; YHR044C2-deoxyglucose-6-phosphate phosphatase 1; 2-DOG-6-P 1; 2-deoxyglucose-6-phosphatase 1; EC 3.1.3.68
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种属
Saccharomyces cerevisiae
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表达系统
Yeast
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P38774
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表达区间
1-246aa
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分子量
29.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
DOG1, or Discovered on Gastrointestinal stromal tumors 1, is a protein that has garnered significant attention due to its role in the pathophysiology of gastrointestinal stromal tumors (GISTs). GISTs are the most common mesenchymal tumors of the gastrointestinal tract, often driven by mutations in the KIT or PDGFRA genes, which lead to constitutive activation of receptor tyrosine kinases. DOG1 serves as a vital marker for diagnosing GISTs, as it is overexpressed in these tumors, making it a potential target for therapeutic interventions. Research into the recombinant DOG1 protein has facilitated the development of diagnostic tools and therapeutic strategies, enhancing our understanding of GIST biology. Studies have explored the structural characteristics and biological functions of DOG1, uncovering its interactions with other cellular components that regulate tumor growth and survival pathways. The recombinant production of DOG1 protein not only aids in elucidating its role in GISTs but also paves the way for exploring its therapeutic potential in combination with existing treatments. Overall, the investigation of DOG1 recombinant protein holds promise for improving GIST diagnosis and therapy, reflecting the need for targeted strategies in managing this challenging malignancy.
