关键信息
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基因名
GFPT2
- 应用
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别名
GFAT2; Glutamine Fructose 6-Phosphate Aminotransferase 2; Hexosephosphate aminotransferase 2; D-fructose-6-phosphate amidotransferase 2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94808
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表达区间
Cys2~Gly288
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分子量
36kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GFPT2, or Glutamine Fructose-6-Phosphate Transaminase 2, is an enzyme that plays a pivotal role in the hexosamine biosynthetic pathway, which is crucial for the production of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a key building block for glycoproteins and glycolipids. Research has highlighted the importance of GFPT2 in cellular processes, particularly in cancer biology, as its overexpression has been linked to tumor progression and metastasis. Moreover, GFPT2 is believed to influence cellular signaling pathways, including those related to insulin resistance and metabolic disorders. Understanding the function and regulatory mechanisms of GFPT2 is critical for uncovering its potential as a therapeutic target. The recombinant protein production of GFPT2 enables detailed structural and functional analyses, allowing researchers to investigate its enzymatic activity, substrate specificity, and interaction with other cellular molecules. These studies are vital for developing strategies to modulate GFPT2 activity, providing insights into its role in disease and offering avenues for novel therapeutic interventions. Overall, GFPT2 represents a significant focus of research within the fields of biochemistry, cell biology, and oncology, underlining its relevance in health and disease.
