WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/50-1/100 | Human,Mouse,Rat |
ICC | 1/50-1/200 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | RAB8A; member RAS oncogene family; MEL; RAB8 |
Entrez GeneID | 4218 |
WB Predicted band size | Calculated MW: 24 kDa; Observed MW: 24 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | A synthetic peptide of human RAB8A |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇与Rab8A抗体相关的参考文献(标题、作者及摘要概括):
1. **"Rab8 modulates cadherin junction formation and cell migration during tissue morphogenesis"**
*Authors: Hattula K, et al.*
摘要:研究利用Rab8A特异性抗体证实其在细胞迁移和钙黏蛋白连接形成中的作用,揭示Rab8A通过调控膜运输影响上皮组织形态发生。
2. **"Rab8 regulates basolateral secretory pathway sorting in epithelial cells"**
*Authors: Peränen J, et al.*
摘要:通过免疫荧光和Western blot分析(使用Rab8A抗体),发现Rab8A参与上皮细胞基底侧分泌途径的蛋白质分选,与Rab11协同调控极化运输。
3. **"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis"**
*Authors: Nachury MV, et al.*
摘要:研究通过Rab8A抗体染色证明Rab8A与BBS蛋白复合物协同调控纤毛膜生成,为纤毛疾病机制提供分子基础。
4. **"The Wnt/planar cell polarity pathway component Vangl2 induces Rab8-Rab11-mediated endocytic recycling"**
*Authors: Angers S, et al.*
摘要:利用Rab8A抗体进行共定位实验,发现Rab8A与Vangl2在Wnt信号通路中调控内吞循环,影响细胞极性建立。
以上文献均通过Rab8A抗体的实验手段(如免疫印迹、免疫荧光等)解析其功能,涵盖细胞运输、极性和疾病等领域。
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