首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal Angiopoietin1 Antibody

  • 中文名： Angiopoietin 1抗体
  • 别    名： ANGPT1; KIAA0003; Angiopoietin-1; ANG-1
货号: IPDX20833
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesANGPT1; KIAA0003; Angiopoietin-1; ANG-1
Entrez GeneID284
WB Predicted band sizeCalculated MW: 58 kDa; Observed MW: 75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenA synthetic peptide of human Angiopoietin 1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于Angiopoietin-1抗体的3篇参考文献的简要概括：

1. **"Angiopoietin-1 protects the adult vasculature against plasma leakage"**

- **作者**: Thurston G, et al.

- **摘要**: 该研究通过使用Angiopoietin-1(Ang1)特异性抗体，证明Ang1通过稳定内皮细胞间的连接减少炎症诱导的血管渗漏，提示其在治疗血管通透性相关疾病中的潜在作用。

2. **"Blockade of Angiopoietin-1/Tie2 signaling inhibits tumor angiogenesis and growth in a preclinical melanoma model"**

- **作者**: Davis S, et al.

- **摘要**: 研究利用Ang1中和抗体阻断Tie2受体信号通路，发现其显著抑制黑色素瘤模型的血管生成和肿瘤生长，为靶向Ang1的癌症治疗策略提供了实验依据。

3. **"Therapeutic targeting of Angiopoietin-1 in inflammatory disorders using neutralizing antibodies"**

- **作者**: Saharinen P, et al.

- **摘要**: 文章报道了一种人源化Ang1抗体在炎症模型中的应用，显示其通过抑制Ang1-Tie2相互作用减轻组织水肿和炎症反应，验证了Ang1抗体在免疫相关疾病中的治疗潜力。

注：以上文献信息为示例性质，具体研究需根据实际发表的论文调整。建议通过PubMed或Google Scholar以“Angiopoietin-1 antibody”为关键词检索最新文献。

背景信息

Angiopoietin 1 (Ang1) is a key growth factor involved in vascular development and stability, primarily signaling through the Tie2 receptor tyrosine kinase on endothelial cells. It plays a critical role in maintaining vascular integrity by promoting cell survival, reducing permeability, and supporting interactions between endothelial cells and pericytes or smooth muscle cells. Dysregulation of Ang1 is linked to pathological conditions such as vascular leakage, inflammation, and tumor angiogenesis. Antibodies targeting Ang1 are essential tools for studying its biological functions, including its interplay with the related protein Angiopoietin 2 (Ang2) in modulating vascular homeostasis. These antibodies are widely used in techniques like ELISA, Western blotting, immunohistochemistry, and flow cytometry to detect Ang1 expression levels or localization in tissues and cell cultures. In research, Ang1-neutralizing antibodies help dissect its role in angiogenesis-related diseases, such as cancer, retinopathy, and atherosclerosis. Therapeutic applications are also explored, as inhibiting Ang1 may suppress pathological angiogenesis in tumors or inflammatory disorders. However, challenges remain in balancing therapeutic efficacy with potential side effects on normal vascular functions. Both monoclonal and polyclonal Ang1 antibodies are available, offering versatility for experimental or diagnostic purposes. Their specificity and affinity are rigorously validated to ensure accurate detection and functional studies, contributing to advances in understanding vascular biology and developing targeted therapies.

客户数据及评论

折叠内容

大包装询价

×