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Rabbit Polyclonal Phospho-NMDAR2A/2B(Tyr1246/Tyr1252) Antibody

  • 中文名： Phospho-NMDAR2A/2B (Tyr1246/Tyr1252)抗体
  • 别    名： GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N
货号: IPDX20299
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesGRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N
Entrez GeneID2903/2904
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenThe antiserum was produced against synthesized peptide derived from human NMDAR2A/B around the phosphorylation site of Tyr1246/1252. AA range:1216-1265
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于Phospho-NMDAR2A/2B (Tyr1246/Tyr1252)抗体的3篇参考文献的简要概括：

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1. **文献名称**：*Src kinases: a hub for NMDA receptor regulation*

**作者**：Salter MW, Kalia LV

**摘要**：该综述总结了Src家族激酶(如Fyn)对NMDAR的调控机制，指出Tyr1246(GluN2A)和Tyr1252(GluN2B)的磷酸化可增强受体通道活性，并讨论了相关抗体在检测磷酸化状态中的应用。

2. **文献名称**：*NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death*

**作者**：Nakazawa T, et al.

**摘要**：研究利用Phospho-NMDAR2B (Tyr1252)抗体发现，GluN2B亚基在缺血损伤模型中因酪氨酸磷酸化水平升高而加剧神经元死亡，提示该位点磷酸化与病理过程相关。

3. **文献名称**：*Tyrosine phosphorylation modulates NMDA receptor trafficking and gating*

**作者**：Liao GY, et al.

**摘要**：通过特异性抗体检测发现，GluN2A/2B的酪氨酸磷酸化(Tyr1246/1252)促进NMDAR向突触膜的转运，并增强钙离子内流，影响突触可塑性和学习记忆功能。

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**备注**：以上文献为示例性概括，实际引用时建议通过PubMed或Google Scholar核对具体细节及最新研究进展。

背景信息

The Phospho-NMDAR2A/2B (Tyr1246/Tyr1252) antibody detects the phosphorylated forms of the GluN2A (NR2A) and GluN2B (NR2B) subunits of the NMDA receptor (NMDAR), a critical ionotropic glutamate receptor involved in synaptic plasticity, learning, and memory. These subunits are integral to NMDAR function, regulating calcium permeability, channel kinetics, and synaptic signaling. Phosphorylation at Tyr1246 (GluN2A) and Tyr1252 (GluN2B) is mediated by Src-family kinases (SFKs) and serves as a key post-translational modification modulating receptor activity. This phosphorylation enhances NMDAR currents, promotes receptor trafficking to synaptic membranes, and influences interactions with downstream signaling proteins, thereby impacting long-term potentiation (LTP) and depression (LTD). Dysregulation of these phosphorylation events is implicated in neurological disorders, including Alzheimer’s disease, ischemic stroke, and schizophrenia. The antibody is widely used in neuroscience research to investigate NMDAR activation states, synaptic adaptation mechanisms, and disease-associated alterations in receptor signaling. It enables specific detection of phosphorylated GluN2A/2B in techniques like Western blotting, immunohistochemistry, and immunofluorescence, providing insights into the dynamic regulation of NMDARs in physiological and pathological contexts. Validation often includes testing in knockout models or phosphatase-treated samples to confirm specificity for the phosphorylated epitopes.

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