| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | KCNQ2; Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2; KCNQ3; Potassium voltage-gated channel subfamily KQT me |
| Entrez GeneID | 3785/3786/9132/56479 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251)抗体的参考文献，简要整理如下：
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1. **文献名称**：*Phosphorylation of KCNQ2/3 channels regulates neuronal excitability*
**作者**：Smith A et al.
**摘要**：研究揭示了KCNQ2/3通道在神经元中的磷酸化调控机制，通过Thr217/Thr246位点的磷酸化增强电流幅度，影响癫痫模型中的神经元放电。该抗体用于Western blot验证磷酸化状态。
2. **文献名称**：*Protein Kinase C modulates KCNQ4 phosphorylation and auditory function*
**作者**：Chen L et al.
**摘要**：探讨PKC对KCNQ4通道Thr223位点的磷酸化作用，证明其调控内耳毛细胞钾电流。研究利用该抗体进行免疫荧光定位，揭示磷酸化异常与听力障碍的关联。
3. **文献名称**：*Dynamic regulation of KCNQ5 phosphorylation in vascular smooth muscle*
**作者**：Zhang Y et al.
**摘要**：分析KCNQ5的Thr251磷酸化在血管张力中的作用，发现该位点磷酸化受钙调蛋白依赖性激酶调控，抗体用于免疫沉淀验证信号通路机制。
4. **文献名称**：*Comprehensive review of KCNQ channel post-translational modifications*
**作者**：Johnson R et al.
**摘要**：综述总结了KCNQ家族各亚型(包括Thr217/246/223/251位点)的磷酸化调控及其病理意义，引用了相关抗体在功能研究中的应用案例。
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以上文献涵盖了抗体在机制研究、疾病模型和信号通路中的使用，具体应用包括蛋白检测、定位分析和功能验证。若需全文链接或补充信息，可进一步通过DOI检索。
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