关键信息
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基因名
UCK2
- 应用
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别名
UK; UMPK; Uridine Monophosphate Kinase; Cytidine monophosphokinase 2; Testis-specific protein TSA903; Uridine monophosphokinase 2
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZX2
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表达区间
Gly18~His261
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分子量
31kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The UCK2 (uridine-cytidine kinase 2) protein has garnered significant attention in recent years due to its essential role in nucleoside metabolism and potential implications in cancer therapy. UCK2 is primarily involved in the phosphorylation of uridine and cytidine, converting them into their respective monophosphate forms, which are crucial for nucleotide synthesis and, consequently, RNA and DNA biosynthesis. Dysregulation of UCK2 activity has been implicated in various malignancies, making it a target of interest in cancer research. Studies have shown that elevated levels of UCK2 can promote tumor cell proliferation and survival, suggesting that inhibition of its activity may offer therapeutic benefits. Furthermore, UCK2 is considered a promising biomarker for certain types of cancers, which has spurred interest in the development of specific inhibitors. The ability to produce recombinant UCK2 proteins allows for in-depth structural and functional studies, enabling researchers to explore its enzymatic mechanisms and interactions with potential inhibitors. Overall, UCK2's critical involvement in nucleoside metabolism and its association with tumorigenesis underscore its relevance in biomedical research, paving the way for novel strategies in cancer treatment and diagnosis.
