Rabbit Monoclonal TRIM24 Antibody

The TRIM24 antibody targets the TRIM24 protein, a member of the Tripartite Motif (TRIM) family characterized by conserved RING, B-box, and coiled-coil domains. TRIM24. also known as TIF1α, functions as an epigenetic regulator and E3 ubiquitin ligase, playing roles in transcriptional regulation, chromatin remodeling, and cellular differentiation. It interacts with chromatin through its plant homeodomain (PHD) and bromodomain, enabling recognition of specific histone modifications, such as H3K23 acetylation, to modulate gene expression. TRIM24 is implicated in oncogenesis, acting as both a tumor suppressor and promoter depending on context. Overexpression is linked to poor prognosis in cancers like breast, liver, and lung, where it may stabilize oncoproteins (e.g., p53 mutants) or enhance pro-growth signaling. Antibodies against TRIM24 are essential tools in studying its expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed TRIM24's involvement in stem cell maintenance, DNA damage response, and hormone signaling pathways, highlighting its potential as a therapeutic target. Validation of TRIM24 antibodies ensures specificity for accurate detection, critical given its structural similarity to other TRIM family members (e.g., TRIM28. TRIM33).