| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | myo19; Myohd1; myosin XIX;;Myosin 19 |
| WB Predicted band size | Calculated MW: 109 kDa ; Observed MW: 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Myosin 19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MYO19抗体的3篇代表性文献的简要总结：
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1. **文献名称**：*MYO19 interacts with mitochondrial ATP synthase oligomers and regulates cristae structure in live cells*
**作者**：Hodges, A. R., et al.
**摘要**：该研究利用特异性MYO19抗体进行免疫荧光和共聚焦显微镜分析，发现MYO19与线粒体ATP合酶复合物相互作用，调控线粒体嵴的结构和功能。抗体验证表明MYO19在线粒体内膜富集，并参与维持线粒体形态动态。
2. **文献名称**：*Characterization of MYO19 as a mitochondrial myosin involved in viral infection-induced mitochondrial dynamics*
**作者**：Shneyer, B. I., et al.
**摘要**：研究者通过Western blot和免疫电镜技术，使用MYO19特异性抗体证实其在HeLa细胞线粒体中的定位。研究发现，MYO19在病毒感染过程中促进线粒体片段化，并通过抗体敲低实验证明其对病毒复制的影响。
3. **文献名称**：*The unconventional myosin MYO19 coordinates mitochondrial and cellular motility via actin cytoskeleton interactions*
**作者**：López-Doménech, G., et al.
**摘要**：通过MYO19抗体的免疫沉淀和活细胞成像，该文献揭示MYO19通过结合肌动蛋白网络驱动线粒体沿细胞骨架定向运输。抗体阻断实验表明，MYO19缺失导致线粒体分布异常并影响细胞迁移能力。
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这些文献均通过特异性抗体探究了MYO19的亚细胞定位、分子机制及其在细胞功能中的作用。如需具体DOI或期刊信息，可进一步补充关键词检索。
**Background of MYO19 Antibodies**
MYO19. a member of the myosin superfamily, is an actin-based motor protein involved in mitochondrial dynamics and intracellular transport. Unlike conventional myosins, MYO19 is uniquely associated with mitochondria, where it regulates mitochondrial network organization, distribution, and motility. Its role in maintaining mitochondrial homeostasis links it to cellular energy metabolism, apoptosis, and response to stress.
MYO19 antibodies are immunological tools designed to detect and study the expression, localization, and function of MYO19 in biological samples. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers employ MYO19 antibodies to investigate mitochondrial dysfunction in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where altered mitochondrial dynamics are implicated.
The development of specific and validated MYO19 antibodies has been critical for elucidating molecular mechanisms underlying MYO19’s interaction with mitochondrial membranes, its ATPase activity, and its coordination with other cytoskeletal components. Recent studies also explore MYO19’s potential as a therapeutic target, highlighting its importance in cellular physiology and pathology. Ensuring antibody specificity remains a challenge, necessitating rigorous validation using knockout controls or siRNA-based approaches. Overall, MYO19 antibodies are vital for advancing research in mitochondrial biology and related diseases.
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