| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DNAJC12; HPANBH4; JDP1; mJDP1;;DNAJC12 |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human DNAJC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于DNAJC12抗体的代表性文献摘要信息：
1. **文献名称**：DNAJC12 deficiency disrupts lysosomal function through impaired HSC70-TFEB signaling
**作者**：Smith A, et al.
**摘要**：研究发现DNAJC12通过调控HSC70-TFEB通路维持溶酶体功能，其抗体检测显示DNAJC12缺失导致神经退行性疾病模型中溶酶体酶活性下降。
2. **文献名称**：A novel DNAJC12 antibody identifies its role in dopamine synthesis and Parkinson’s pathology
**作者**：Chen L, et al.
**摘要**：开发了一种特异性DNAJC12抗体，揭示其在多巴胺代谢中辅助酪氨酸羟化酶折叠的作用，并与帕金森病患者脑组织中的蛋白质聚集相关。
3. **文献名称**：DNAJC12 antibody-based screening reveals its tumor suppressor role in colorectal cancer
**作者**：Wang Y, et al.
**摘要**：通过免疫组化分析发现，DNAJC12在结直肠癌中表达下调，其抗体标记显示其通过调控β-catenin降解抑制肿瘤增殖和转移。
4. **文献名称**：DNAJC12 mutations and antibody-guided functional validation in hyperphenylalaninemia
**作者**：García-Cazorla A, et al.
**摘要**：利用DNAJC12抗体验证了其基因突变导致苯丙氨酸羟化酶伴侣功能缺陷，与高苯丙氨酸血症的遗传机制直接相关。
注：以上为示例性内容，实际文献需通过PubMed/Google Scholar检索关键词“DNAJC12 antibody”或结合具体研究领域筛选。
The DNAJC12 antibody is a research tool designed to detect and analyze DNAJC12. a member of the J-protein family (HSP40) that acts as a co-chaperone for HSP70 proteins. DNAJC12 facilitates HSP70-mediated protein folding, trafficking, and degradation by stimulating ATPase activity and substrate binding. It is ubiquitously expressed but enriched in tissues with high metabolic activity, such as the liver, brain, and kidneys. Dysregulation of DNAJC12 has been linked to neurological disorders, cancer, and metabolic diseases. Notably, mutations in DNAJC12 are associated with mild forms of phenylketonuria (PKU) or hyperphenylalaninemia due to its role in stabilizing phenylalanine hydroxylase (PAH).
The DNAJC12 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interactions in cellular and disease models. It aids in investigating DNAJC12's involvement in stress response pathways, protein quality control, and neuroprotection. Recent studies highlight its potential as a biomarker or therapeutic target in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, where protein misfolding contributes to pathology. Researchers also utilize this antibody to explore DNAJC12's impact on cancer progression, particularly in modulating oncogenic signaling and drug resistance.
Overall, the DNAJC12 antibody serves as a critical reagent for unraveling molecular mechanisms underlying cellular homeostasis and disease, bridging gaps between chaperone dysfunction and human pathologies.
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