Cat: IPD-X38454

Recombinant Human LAMb4 Protein,His

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关键信息

  • 基因名

    LAMb4

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Laminin beta-1-related protein

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N-His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    A4D0S4

  • 表达区间

    Asn1543~Cys1759

  • 分子量

    28kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

LAMb4 (Laminin beta-4) is a crucial extracellular matrix protein that plays a significant role in various physiological processes, including cell adhesion, migration, and differentiation. It is a part of the laminin family of glycoproteins, which are vital for maintaining structural integrity in tissues. Research has shown that LAMb4 is essential in the development and function of several biological systems, particularly in the nervous and muscular systems. Its expression is often correlated with various pathological conditions, including cancer metastasis, where it may facilitate tumor cell invasion, and neurodegenerative diseases, where it may influence neuronal repair pathways. As interest in targeted therapies and regenerative medicine grows, LAMb4 has emerged as a potential biomarker for disease progression and a promising target for therapeutic interventions. Scientists are increasingly focused on characterizing LAMb4's interactions with cell receptors, as well as its functional implications in both healthy and diseased states. Understanding the molecular mechanisms underlying LAMb4's role could lead to advancements in treatment strategies for diseases linked to extracellular matrix alterations, enhancing the field of biomedical research and improving patient outcomes. This growing body of research aims to unravel the multifaceted roles of LAMb4, providing insights that could transform approaches to tissue engineering and regenerative medicine.

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