关键信息
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基因名
GINS2
- 应用
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别名
GINS complex subunit 2
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y248
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表达区间
1-185aa
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分子量
37.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GINS2, a component of the GINS complex, plays a critical role in DNA replication and cell cycle regulation. This protein is part of a multi-subunit complex that interacts with other essential replication factors, aiding in the formation of the DNA replication fork. Research has shown that GINS2 is essential for the stability and efficiency of DNA synthesis, and its dysfunction is implicated in various cancers and developmental disorders. Studies have focused on understanding the structural and functional mechanisms of GINS2, revealing its interactions with helicases and polymerases, which are pivotal for replicative fidelity. Additionally, GINS2's involvement in the coordination of leading and lagging strand synthesis highlights its importance in the overall process of DNA replication. Given its vital roles, GINS2 is considered a potential biomarker for tumorigenesis and a target for therapeutic interventions in cancer treatment. Advancements in recombinant protein techniques have facilitated detailed studies of GINS2, enabling researchers to explore its biochemical properties and interactions in various cellular contexts. Overall, the investigation of GINS2 not only provides insights into fundamental biological processes but also holds promise for novel therapeutic strategies in oncology.
