| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SRP19;;SRP19 |
| WB Predicted band size | Calculated MW: 16 kDa ; Observed MW: 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SRP19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于SRP19抗体的3篇参考文献的简要信息(注：以下内容为模拟示例，具体文献需根据实际数据库检索验证)：
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1. **文献名称**：*Structural insights into the assembly of the human signal recognition particle with SRP19*
**作者**：Kuglstatter A. et al.
**摘要**：研究通过X射线晶体学解析了SRP19与SRP RNA复合物的结构，揭示了SRP19在信号识别颗粒(SRP)组装中的关键作用。实验中利用特异性SRP19抗体验证了蛋白质在复合体中的结合模式。
2. **文献名称**：*Autoantibodies against signal recognition particle in immune-mediated myopathy*
**作者**：Satoh M. et al.
**摘要**：探讨了抗SRP抗体(包括SRP19亚基抗体)在特发性炎性肌病中的诊断价值，发现此类抗体与疾病严重程度相关，并通过ELISA和免疫印迹法验证了其特异性。
3. **文献名称**：*Functional characterization of SRP19 in protein targeting pathways*
**作者**：Wild K. et al.
**摘要**：利用基因敲除细胞模型和SRP19特异性抗体，证明SRP19缺失导致蛋白质转运功能受损，并通过免疫荧光技术定位了SRP19在细胞内的分布。
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建议通过PubMed或Google Scholar以关键词“SRP19 antibody”、“anti-SRP19”或“SRP19 function”检索真实文献，并筛选涉及抗体开发、应用或机制研究的论文。
The SRP19 antibody is a research tool used to study the Signal Recognition Particle (SRP) 19 kDa protein, a critical component of the SRP complex. SRP is a ribonucleoprotein complex essential for co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP19. a conserved RNA-binding protein, stabilizes the SRP RNA scaffold by binding to its Alu domain and facilitates the assembly of SRP54. the key subunit responsible for recognizing signal sequences on nascent polypeptides. Dysregulation of SRP-mediated protein translocation is linked to cellular stress, developmental disorders, and diseases like cancer.
SRP19 antibodies are primarily used in molecular biology to investigate SRP assembly, RNA-protein interactions, and ER targeting mechanisms. They enable detection and quantification of SRP19 via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers also utilize these antibodies to explore SRP19's role in pathological contexts, such as tumor progression or rare genetic disorders affecting protein secretion. Commercial SRP19 antibodies are typically raised in rabbits or mice, validated for specificity against recombinant or endogenous proteins.
Understanding SRP19's function through antibody-based studies provides insights into fundamental cellular processes and potential therapeutic strategies for diseases involving defective protein trafficking.
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