| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CMAVM; GAP; p120GAP; p120RASGAP; PKWS; RASA; RASA1; RasGAP;;RASA1 |
| WB Predicted band size | Calculated MW: 116 kDa ; Observed MW: 140 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human RASA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于RASA1抗体的3篇参考文献示例(内容为模拟生成，实际文献需通过学术数据库检索)：
---
1. **文献名称**: *RASA1 regulates vascular permeability through VE-cadherin and p120-catenin phosphorylation*
**作者**: Smith A, et al.
**摘要**: 本研究利用RASA1特异性抗体(如sc-52431)通过免疫共沉淀和Western blot技术，揭示了RASA1通过调控VE-cadherin和p120-catenin的磷酸化影响血管内皮屏障功能，为遗传性血管畸形提供了分子机制解释。
2. **文献名称**: *Loss of RASA1 in neural crest cells leads to altered cardiac development*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(RASA1抗体：Abcam ab12345)在小鼠模型中观察到RASA1蛋白在心脏神经嵴细胞的表达缺失，导致主动脉弓发育异常，证实RASA1对胚胎期心血管系统的关键调控作用。
3. **文献名称**: *RASA1 mutations and protein expression in capillary malformation-arteriovenous malformation syndrome*
**作者**: Wang Y, et al.
**摘要**: 该研究使用RASA1抗体对患者皮肤病变组织进行免疫荧光染色，发现RASA1突变导致蛋白表达量显著降低，并伴随MAPK信号通路异常激活，为临床诊断提供了生物标志物依据。
---
**备注**：实际文献需通过PubMed、Google Scholar等平台检索关键词“RASA1 antibody”或“RASA1 protein analysis”，并关注抗体应用场景(如Western blot、IHC等)。部分常用RASA1抗体厂商包括Santa Cruz(sc-52431)、Abcam(ab52947)等。
The RASA1 antibody targets the Ras GTPase-activating protein (RasGAP) encoded by the *RASA1* gene, a critical regulator of cellular signaling pathways. RASA1 functions as a negative modulator of RAS proteins by accelerating their GTP hydrolysis, thereby inactivating RAS-mediated signals that control cell proliferation, differentiation, and survival. This protein plays a pivotal role in vascular development, angiogenesis, and maintaining endothelial cell integrity.
Mutations in *RASA1* are linked to human disorders such as capillary malformation-arteriovenous malformation (CM-AVM) syndrome, characterized by vascular anomalies. RASA1 antibodies are essential tools in research to study protein expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess RASA1 levels in tissues or cell lines, particularly in cancer studies where RAS pathway dysregulation is common.
Additionally, RASA1 antibodies aid in exploring mechanisms underlying vascular defects and endothelial dysfunction. Their application extends to preclinical models to evaluate therapeutic strategies targeting RAS/MAPK signaling. By detecting RASA1 loss or aberrant expression, these antibodies contribute to understanding disease pathogenesis and potential biomarkers for diagnosis or treatment response. Overall, RASA1 antibodies are vital for dissecting RAS signaling dynamics and its implications in development and disease.
×
