| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | COX6B; COX6B1; COXG; COXVIb1;;COX 6B1 |
| WB Predicted band size | 10 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human COX 6B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于COX6B1抗体的3篇示例性参考文献(注：文献信息为虚构示例，仅作格式参考)：
1. **文献名称**: "COX6B1 Antibody Validation in Mitochondrial Disease Models"
**作者**: Smith A, et al.
**摘要**: 通过Western blot和免疫荧光验证COX6B1抗体的特异性，发现其在患者线粒体复合体IV缺陷样本中表达显著降低，提示其作为诊断标志物的潜力。
2. **文献名称**: "Role of COX6B1 in Cancer Metabolism: Antibody-Based Profiling"
**作者**: Zhang L, et al.
**摘要**: 利用COX6B1抗体分析肿瘤组织，揭示其在肺癌中高表达，并通过调控氧化磷酸化促进癌细胞增殖，为靶向治疗提供依据。
3. **文献名称**: "COX6B1 Knockout Mice and Antibody Localization Studies"
**作者**: Tanaka K, et al.
**摘要**: 通过基因敲除模型和免疫组化技术，证实COX6B1抗体特异性标记心肌细胞线粒体，揭示其缺失导致心脏功能异常。
---
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“COX6B1 antibody”，筛选涉及抗体应用(如WB/IHC)、功能研究或疾病关联的论文。
The cytochrome c oxidase subunit 6B1 (COX6B1) is a nuclear-encoded subunit of cytochrome c oxidase (Complex IV), the terminal enzyme in the mitochondrial electron transport chain responsible for ATP synthesis. COX6B1 is integral to the assembly and function of Complex IV, which catalyzes the transfer of electrons from cytochrome c to molecular oxygen. Antibodies targeting COX6B1 are widely used to study its expression, localization, and role in mitochondrial respiration and cellular energy metabolism.
COX6B1 antibodies are essential tools in applications like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cells, particularly in research on mitochondrial disorders, cancer, and neurodegenerative diseases. Dysregulation of COX6B1 has been linked to conditions such as prostate cancer, hypoxia-related pathologies, and Leigh syndrome. Validated antibodies help investigate COX6B1's interaction partners, post-translational modifications, and tissue-specific expression patterns.
Most commercial COX6B1 antibodies are raised in rabbits or mice using peptide antigens corresponding to conserved regions of the human protein. Specificity is confirmed via knockout controls or siRNA knockdown. Researchers prioritize antibodies with high affinity and minimal cross-reactivity to other COX subunits. These reagents contribute to elucidating mitochondrial dysfunction mechanisms and potential therapeutic targets in energy metabolism-related diseases.
×
