| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myh7b; Myosin-7B;;Myosin heavy chain 7B |
| WB Predicted band size | Calculated MW: 226 kDa ; Observed MW: 221 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Myosin heavy chain 7B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于MYH7B抗体的3篇参考文献概览，基于虚构内容模拟相关研究方向：
1. **文献名称**：*MYH7B expression in cardiac hypertrophy: Antibody validation and functional implications*
**作者**：Zhang et al.
**摘要**：本研究验证了一种特异性MYH7B抗体的可靠性，通过免疫组化和Western blot分析其在心脏肥大模型中的表达上调，提示MYH7B可能在病理心肌重构中发挥作用。
2. **文献名称**：*Developmental regulation of MYH7B in skeletal muscle: Insights from antibody-based profiling*
**作者**：Chen & Wang
**摘要**：利用MYH7B抗体对小鼠骨骼肌发育不同阶段进行蛋白定位，发现其在胚胎期高表达，提示其对肌纤维成熟的关键调控作用。
3. **文献名称**：*MYH7B antibody reveals distinct isoform-specific interactions in cardiomyocytes*
**作者**：Martinez et al.
**摘要**：通过免疫共沉淀结合质谱分析，发现MYH7B与肌节蛋白Z-disc组分存在特异性结合，其抗体为解析心肌细胞收缩机制提供了工具。
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注：以上内容为示例，实际文献需通过PubMed或Google Scholar检索关键词“MYH7B antibody”获取。真实研究可能聚焦于抗体验证、疾病标记物筛选或分子机制探索。
The MYH7B antibody targets the protein encoded by the MYH7B gene, a member of the myosin heavy chain (MYH) family. Myosin heavy chains are critical components of sarcomeres in muscle cells, contributing to contractile functions. MYH7B, also classified as MYH14. is part of the class II myosin group and is expressed in specific tissues, including skeletal muscle, heart, and certain smooth muscles. Unlike its closely related isoform MYH7 (β-myosin heavy chain), which is predominantly cardiac, MYH7B has a broader expression pattern and may play roles in both muscle contraction and non-muscle cellular processes.
Research on MYH7B has gained attention due to its potential involvement in diseases. Mutations in MYH7B have been linked to inherited cardiomyopathies, such as hypertrophic cardiomyopathy (HCM), and certain cancers. The antibody serves as a vital tool for detecting MYH7B protein levels in tissues, enabling studies on its expression patterns, localization, and functional mechanisms. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence.
Commercial MYH7B antibodies are typically developed using immunogenic peptide sequences unique to the protein, ensuring specificity. Validation steps include testing on knockout cell lines or tissues to confirm minimal cross-reactivity. Understanding MYH7B's role through antibody-based research could provide insights into disease pathways and therapeutic targets, particularly in cardiac and oncological contexts. Ongoing studies aim to clarify its regulatory mechanisms and interactions within cellular networks.
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