| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HPC 1; P35-1; STX1; STX1A; SYN1A; Syntaxin-1A;;Syntaxin 1A |
| WB Predicted band size | 33 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Syntaxin 1A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于STX1A抗体的3篇参考文献的简要概括：
1. **文献名称**：*"Syntaxin 1A Antibody as a Potential Biomarker for Neuroendocrine Tumors"*
**作者**：Smith J, et al.
**摘要**：该研究利用STX1A抗体通过免疫组化技术检测神经内分泌肿瘤组织中Syntaxin 1A的表达，发现其高表达与肿瘤分化程度和预后相关，提示其可能作为诊断标志物。
2. **文献名称**：*"Altered Syntaxin 1A Levels in Alzheimer's Disease: An Immunoblot Analysis"*
**作者**：Lee H, et al.
**摘要**：通过Western blot和免疫荧光技术，研究发现阿尔茨海默病模型小鼠脑组织中STX1A蛋白水平显著降低，表明其可能与突触功能障碍及病理进程相关。
3. **文献名称**：*"STX1A Antibody Reveals Dysregulated Synaptic Vesicle Recycling in Schizophrenia"*
**作者**：Garcia R, et al.
**摘要**：该文献使用STX1A抗体分析精神分裂症患者死后脑组织，发现前额叶皮层Syntaxin 1A表达异常，提示突触囊泡运输障碍可能参与疾病机制。
4. **文献名称**：*"Role of Syntaxin 1A in Pancreatic Beta-Cell Insulin Secretion: Antibody-Based Functional Studies"*
**作者**：Chen L, et al.
**摘要**：通过抗体阻断和基因沉默实验，证实STX1A在胰岛β细胞胰岛素分泌中的关键作用，为糖尿病治疗提供潜在靶点。
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注：上述内容为示例性概括，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。建议使用关键词“STX1A antibody”或“Syntaxin 1A + 应用领域”进一步筛选近期研究。
The STX1A antibody targets Syntaxin-1A, a key protein in the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family involved in synaptic vesicle exocytosis and neurotransmitter release. Predominantly expressed in neuronal and neuroendocrine cells, Syntaxin-1A localizes to presynaptic membranes, mediating vesicle docking and fusion with the plasma membrane via interactions with proteins like SNAP-25 and synaptobrevin. Its role in regulating calcium-triggered synaptic transmission makes it critical for studying synaptic plasticity, neural communication, and disorders like epilepsy, Parkinson’s disease, and autism.
STX1A antibodies are widely used in neuroscience research to detect protein expression, map synaptic structures, and investigate trafficking mechanisms. Common applications include Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are often validated for specificity using knockout controls or siRNA-based silencing. Commercial STX1A antibodies are typically raised in rabbits or mice, with monoclonal and polyclonal variants available.
Altered Syntaxin-1A levels or mutations have been linked to synaptic dysfunction, making its antibody a tool for probing pathological mechanisms in neurodegenerative diseases and psychiatric conditions. Recent studies also explore its involvement in endocrine secretion and cancer cell exocytosis. Researchers must consider epitope regions (e.g., N-terminal or C-terminal domains) and cross-reactivity with Syntaxin-1B, a closely related isoform, when selecting antibodies for experimental design.
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