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Rabbit Monoclonal DLDH Antibody

  • 中文名: DLDH抗体
  • 别    名: Diaphorase; Dihydrolipoamide dehydrogenase; DLDD; DLDH; GCSL; LAD; lipoamide dehydrogenase; Lipoamide reductase; Lipoyl dehydrogenase; PHE3;;DLD
货号: IPDX18786
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDiaphorase; Dihydrolipoamide dehydrogenase; DLDD; DLDH; GCSL; LAD; lipoamide dehydrogenase; Lipoamide reductase; Lipoyl dehydrogenase; PHE3;;DLD
WB Predicted band sizeCalculated MW: 54 kDa ; Observed MW: 56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human DLD
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于DLDH(假设为乳酸脱氢酶相关抗体)的3篇参考文献示例,基于领域内常见研究方向整理:

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1. **文献名称**:*Autoantibodies against D-Lactate Dehydrogenase in Autoimmune Hepatitis*

**作者**:Smith J, et al.

**摘要**:本研究报道了在自身免疫性肝炎患者血清中检测到针对D-乳酸脱氢酶(D-LDH)的自身抗体,提示其可能作为疾病的新型生物标志物,并探讨了抗体与肝细胞损伤的关联机制。

2. **文献名称**:*Development of a Monoclonal Antibody Specific to Human LDH-C4 for Cancer Diagnostics*

**作者**:Chen L, et al.

**摘要**:研究团队开发了一种靶向人LDH-C4(睾丸型乳酸脱氢酶)的高特异性单克隆抗体,验证了其在多种癌症组织中的高表达,并证明其可用于免疫组化检测和液体活检中的肿瘤标志物分析。

3. **文献名称**:*Mitochondrial LDH-targeted Antibodies Reveal Metabolic Reprogramming in Glioblastoma*

**作者**:Wang Y, et al.

**摘要**:通过构建靶向线粒体乳酸脱氢酶(mLDH)的抗体,揭示了胶质母细胞瘤细胞中LDH亚细胞定位的异常现象,证实其与肿瘤代谢重编程和化疗耐药性之间的潜在关联。

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**说明**:

- 若“DLDH”特指某亚型(如线粒体LDH或特定物种同工酶),建议结合具体研究背景调整关键词。

- 实际文献需通过数据库(PubMed/Google Scholar)按准确术语检索,此处为示例性概括。

背景信息

The D-lactate dehydrogenase (DLDH) antibody is a tool used to detect and study the enzyme D-lactate dehydrogenase, which catalyzes the conversion of D-lactate to pyruvate in the reversible oxidation of D-lactic acid. Unlike the more common L-lactate dehydrogenase (LDH), DLDH specifically acts on the D-isomer of lactate, a metabolite often associated with microbial fermentation or pathological conditions in mammals. D-lactic acidosis, linked to gut dysbiosis, short bowel syndrome, or metabolic disorders, involves elevated D-lactate levels, making DLDH a biomarker of interest. DLDH antibodies are utilized in research to investigate enzyme expression, localization, and function in tissues, particularly in studies involving mitochondrial metabolism, anaerobic energy pathways, and diseases like diabetes, cancer, or neurological disorders. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, aiding in understanding DLDH's role in cellular redox balance, energy production, and its potential involvement in pathological lactate accumulation. Recent studies also explore DLDH in microbial communities, emphasizing its relevance in host-microbe interactions and metabolic diseases.

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