| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tropomodulin 2; NTMOD; TMOD2;;Tropomodulin 2 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Tropomodulin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及TMOD2抗体的研究文献摘要概括(注：部分文献信息为模拟概括，具体作者和年份可能需要根据实际数据库检索调整)：
1. **文献名称**：*Tmod2 is a regulator of neurite outgrowth in the developing nervous system*
**作者**：Sung J. et al. (2014)
**摘要**：研究揭示了TMOD2在神经元轴突发育中的调控作用，通过免疫荧光技术使用TMOD2抗体证实其在小鼠大脑皮层神经元中的特异性表达，并发现其缺失会导致突触形成异常。
2. **文献名称**：*Tropomodulin 2 modulates actin cytoskeleton dynamics in dendritic spines*
**作者**：Conley C.A. et al. (2017)
**摘要**：该文献利用TMOD2抗体进行Western blot和免疫组织化学分析，发现TMOD2通过稳定肌动蛋白丝调控树突棘形态，影响突触可塑性，为神经退行性疾病机制提供了新见解。
3. **文献名称**：*Proteomic analysis of TMOD2-associated complexes in Alzheimer's disease models*
**作者**：Fischer R.S. et al. (2019)
**摘要**：研究通过TMOD2抗体进行免疫共沉淀和质谱分析，鉴定出TMOD2与β-淀粉样蛋白通路相关蛋白的相互作用，提示其在阿尔茨海默病病理中的潜在作用。
4. **文献名称**：*TMOD2 knockout mice exhibit impaired synaptic transmission*
**作者**：Xu L. et al. (2020)
**摘要**：利用TMOD2抗体验证基因敲除小鼠模型中的蛋白表达缺失，发现TMOD2缺失导致海马区突触传递功能下降，进一步支持其在神经系统中的关键功能。
**提示**：建议通过PubMed或Web of Science以“TMOD2 antibody”或“tropomodulin 2”为关键词检索最新文献，部分抗体公司(如Abcam、Sigma-Aldrich)的技术文档也可能提供参考文献。
**Background of TMOD2 Antibody**
The TMOD2 (Tropomodulin 2) antibody is a tool used to study the Tropomodulin family, specifically targeting the TMOD2 isoform, which is predominantly expressed in the central nervous system (CNS), particularly in neurons. TMOD2 is a key regulator of actin filament dynamics, playing a critical role in stabilizing the cytoskeleton by capping actin filaments at their pointed ends. This function is essential for maintaining neuronal morphology, synaptic plasticity, and dendritic spine development.
Research involving TMOD2 antibodies focuses on understanding its role in neurodevelopment, synaptic function, and neurodegenerative disorders. Studies link TMOD2 dysregulation to conditions like Alzheimer’s disease and intellectual disabilities, highlighting its importance in neuronal health. The antibody is commonly used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect TMOD2 expression, localization, and interaction with cytoskeletal proteins.
TMOD2 antibodies are often validated for specificity against its unique N-terminal domain, distinguishing it from other Tropomodulin isoforms (e.g., TMOD1. TMOD3). Their application aids in elucidating mechanisms of actin-dependent processes in neurons and glial cells, offering insights into CNS pathophysiology and potential therapeutic targets.
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