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Rabbit Monoclonal WRN Antibody

  • 中文名： WRN抗体
  • 别    名： Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN;;WRN
货号: IPDX18783
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesExonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN;;WRN
WB Predicted band sizeCalculated MW: 162 kDa ; Observed MW: 200 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human WRN
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于WRN抗体的3篇参考文献示例，涵盖其在不同研究中的应用：

1. **文献名称**：*WRN Protein Expression in Human Cancer: A Potential Biomarker for Patient Prognosis*

**作者**：Smith A, et al.

**摘要**：该研究通过免疫组化(使用WRN特异性抗体)分析多种癌症组织中WRN蛋白的表达水平，发现其高表达与结直肠癌患者不良预后相关，提示WRN可能作为肿瘤治疗的潜在靶点。

2. **文献名称**：*Functional Analysis of Werner Syndrome Helicase in DNA Repair Pathways*

**作者**：Tanaka K, et al.

**摘要**：利用WRN抗体进行Western blot和免疫荧光实验，证实WRN蛋白在DNA损伤修复中的定位变化，并发现其与BRCA1的相互作用对维持基因组稳定性至关重要。

3. **文献名称**：*Loss of WRN Protein in Werner Syndrome Fibroblasts: Implications for Cellular Senescence*

**作者**：Chen L, et al.

**摘要**：通过WRN抗体检测Werner综合征患者成纤维细胞，发现WRN蛋白表达缺失导致细胞早衰和DNA复制障碍，为疾病机制提供了直接证据。

(注：以上文献为示例，实际引用需根据具体研究检索真实数据库。)

背景信息

The WRN antibody is designed to target the Werner syndrome ATP-dependent helicase (WRN), a nuclear protein encoded by the *WRN* gene. WRN belongs to the RecQ helicase family, crucial for maintaining genomic stability by resolving DNA secondary structures, facilitating repair, replication, and recombination. Mutations in *WRN* cause Werner syndrome, a rare autosomal disorder characterized by premature aging, genomic instability, and heightened cancer risk. WRN protein contains helicase and exonuclease domains, enabling its role in DNA damage response, telomere maintenance, and suppression of illegitimate recombination. Research on WRN antibodies focuses on elucidating its molecular functions in aging, cancer, and DNA repair pathways. These antibodies are vital tools in detecting WRN expression levels, localization, and interactions via techniques like Western blot, immunofluorescence, or immunohistochemistry. Studies also explore WRN's synthetic lethality in microsatellite-unstable cancers, proposing it as a therapeutic target. Dysfunctional WRN is linked to replication stress sensitivity, making its study relevant for understanding chemotherapy responses. WRN antibodies thus contribute to both basic research on aging-related mechanisms and translational oncology, offering insights into targeted therapies for cancers reliant on WRN-mediated DNA repair.

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