| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Axam2; Senp2; Sentrin specific protease 2; SMT3 specific isopeptidase 2; Smt3ip2;;SENP2 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human SENP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是关于SENP2抗体的3篇示例参考文献(文献信息为示例性质，具体文献请通过学术数据库检索)：
---
1. **文献名称**: *"SENP2 regulates cardiomyocyte differentiation through deSUMOylation of β-catenin"*
**作者**: Li Y, et al.
**摘要**: 本研究利用SENP2特异性抗体，通过Western blot和免疫组化技术，发现SENP2通过去SUMO化β-catenin调控Wnt信号通路，影响心脏发育和小鼠胚胎干细胞向心肌细胞的分化。
2. **文献名称**: *"SENP2 deletion in mice induces lipid accumulation via HIF-1α stabilization"*
**作者**: Wang J, et al.
**摘要**: 通过构建SENP2基因敲除小鼠模型，结合SENP2抗体检测组织表达，发现SENP2缺失导致HIF-1α去SUMO化受阻，促进脂肪生成相关基因表达，揭示了SENP2在代谢调控中的作用。
3. **文献名称**: *"SENP2 modulates cancer metastasis by regulating MMP-9 expression"*
**作者**: Kim H, et al.
**摘要**: 使用SENP2抗体进行免疫沉淀实验，发现SENP2通过去SUMO化转录因子NF-κB，抑制MMP-9的表达，从而降低乳腺癌细胞的侵袭和转移能力。
---
建议通过PubMed、Google Scholar等平台以关键词“SENP2 antibody”、“SENP2 function”检索最新研究。
The SENP2 antibody is a crucial tool for studying the Sentrin/SUMO-specific protease 2 (SENP2), a member of the SUMO-specific protease family. SENP2 regulates post-translational modification by catalyzing the cleavage of Small Ubiquitin-like Modifier (SUMO) proteins from target substrates, a process essential for maintaining cellular homeostasis. It plays a key role in modulating SUMOylation dynamics, impacting critical pathways such as transcriptional regulation, DNA repair, cell cycle progression, and stress responses. Dysregulation of SENP2 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.
SENP2 antibodies are widely used in research to detect and quantify SENP2 expression in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They also facilitate functional studies, such as identifying SENP2-interacting proteins through co-immunoprecipitation. These antibodies are critical for exploring SENP2's role in disease mechanisms, particularly its dual function as both a tumor suppressor and promoter in different cancer contexts. Researchers rely on validated SENP2 antibodies to ensure specificity, given the structural similarities among SENP family members. Commercial antibodies are typically raised against conserved epitopes, with applications spanning basic research and therapeutic target validation.
×
