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Rabbit Monoclonal DCTN3 Antibody

  • 中文名： DCTN3抗体
  • 别    名： DCNT22; DCTN22; Dctn3; dynactin 3 (p22); dynactin light chain; Dynactin subunit 3; p22;;Dynactin 3
货号: IPDX18776
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesDCNT22; DCTN22; Dctn3; dynactin 3 (p22); dynactin light chain; Dynactin subunit 3; p22;;Dynactin 3
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Dynactin 3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于DCTN3抗体的3篇参考文献及其摘要概括：

1. **文献名称**: *Dynactin subunit p22 is a critical regulator of mitotic progression*

**作者**: Quintyne, N.J., et al.

**摘要**: 研究利用DCTN3(p22)特异性抗体，发现其在有丝分裂中调控动力蛋白-微管相互作用，抑制DCTN3会导致染色体排列异常，提示其在细胞分裂中的关键作用。

2. **文献名称**: *Characterization of dynactin subunits in neuronal development and neurodegeneration*

**作者**: Levy, J.R., et al.

**摘要**: 通过DCTN3抗体检测其在神经元中的表达，发现DCTN3与轴突运输相关，其功能异常可能导致神经退行性疾病，为病理机制研究提供依据。

3. **文献名称**: *Proteomic analysis of dynactin interactome reveals its role in cellular cargo transport*

**作者**: Yeh, T.Y., et al.

**摘要**: 采用DCTN3抗体进行免疫沉淀，鉴定其与动力蛋白复合体的相互作用网络，阐明DCTN3在细胞内物质运输中的核心功能及调控机制。

(注：以上文献信息为示例，实际引用需根据具体论文调整。)

背景信息

The DCTN3 antibody targets the dynactin subunit 3 (DCTN3), a critical component of the dynactin complex, which regulates intracellular transport mediated by cytoplasmic dynein. Dynactin, a multi-subunit protein complex, enhances dynein's ability to move cellular cargo (e.g., vesicles, organelles) along microtubules. DCTN3. also known as p22. stabilizes the dynactin structure by linking the Arp1 filament to other subunits. Dysregulation of dynactin or dynein is implicated in neurodegenerative diseases (e.g., amyotrophic lateral sclerosis) and developmental disorders due to impaired axonal transport. DCTN3 antibodies are widely used in research to study dynactin assembly, intracellular trafficking mechanisms, and disease pathogenesis. They enable detection of DCTN3 expression levels via techniques like Western blot, immunohistochemistry, and immunofluorescence, helping to elucidate its role in cellular homeostasis. Recent studies also explore DCTN3's potential as a biomarker or therapeutic target in dynein-related pathologies.

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