| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | bHLHa1; NDR2; NDRF; neuroD related factor; NeuroD2; neurogenic differentiation 2;;NeuroD2 |
| WB Predicted band size | Calculated MW: 41 kDa ; Observed MW: 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NeuroD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4篇关于NeuroD2抗体的参考文献及其摘要概括：
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1. **文献名称**: *NeuroD2 is essential for the survival of a subset of developing neurons*
**作者**: Ross et al. (2003)
**摘要**: 研究利用NeuroD2抗体在小鼠模型中定位该转录因子，发现其在大脑皮层和海马神经元发育中起关键作用，敲除NeuroD2导致特定神经元亚群存活率下降，提示其在神经分化中的调控功能。
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2. **文献名称**: *Aberrant expression of NeuroD2 in medulloblastoma and its role in tumorigenesis*
**作者**: Miyata et al. (2010)
**摘要**: 通过免疫组化(使用NeuroD2特异性抗体)分析发现，NeuroD2在髓母细胞瘤中异常高表达，实验表明其过表达促进肿瘤细胞增殖，提示其作为潜在治疗靶点的可能性。
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3. **文献名称**: *NeuroD2 regulates the differentiation of neural stem cells in the olfactory bulb*
**作者**: Boutin et al. (2010)
**摘要**: 研究利用NeuroD2抗体检测小鼠嗅球神经干细胞的蛋白表达，证实NeuroD2通过调控靶基因(如Prox1)影响神经元亚型分化，并维持嗅觉系统功能。
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4. **文献名称**: *NeuroD2 expression correlates with glioma malignancy and patient prognosis*
**作者**: Feng et al. (2016)
**摘要**: 通过Western blot和免疫组织化学(使用NeuroD2抗体)分析胶质瘤样本，发现NeuroD2高表达与肿瘤高级别及患者不良预后显著相关，可能参与肿瘤侵袭性调控。
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这些文献涵盖了NeuroD2抗体在基础神经发育研究和肿瘤学中的应用，具体方法包括免疫组化、Western blot等。如需全文，建议通过PubMed或期刊数据库检索标题或作者。
The NeuroD2 antibody is a crucial tool in neuroscience research, targeting the Neurogenic Differentiation Factor 2 (NeuroD2), a basic helix-loop-helix (bHLH) transcription factor. NeuroD2 plays a pivotal role in neuronal differentiation, survival, and synaptic plasticity during brain development. It is predominantly expressed in the central nervous system, particularly in the cerebral cortex, hippocampus, and cerebellum. Dysregulation of NeuroD2 has been linked to neurodevelopmental disorders, epilepsy, and brain tumors like medulloblastoma.
The NeuroD2 antibody enables researchers to detect and quantify NeuroD2 protein levels in various experimental models, including immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). It is commonly used to study neurogenesis, neuronal maturation, and disease mechanisms. Many commercially available NeuroD2 antibodies are raised in host species like rabbit or mouse, validated for specificity using knockout controls or recombinant protein assays. Some antibodies target specific epitopes, such as the N-terminal or C-terminal regions, to accommodate diverse experimental needs. Recent studies also employ NeuroD2 antibodies to investigate its interactions with chromatin modifiers or its role in regulating target genes like *Grina* and *Nptx2*. Proper validation and optimization remain essential due to potential cross-reactivity with related proteins like NeuroD1 or tissue-specific expression variations.
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