| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | BM88;;CEND1 |
| WB Predicted band size | Calculated MW: 15 kDa ; Observed MW: 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CEND1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CEND1抗体的3篇参考文献示例(注：文献为虚构示例，实际研究请查阅专业数据库)：
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1. **"CEND1 regulates neuronal differentiation through cell cycle exit in cortical progenitors"**
*Authors: Smith A, et al.*
摘要：本研究利用CEND1特异性抗体，通过免疫组化和Western blot分析，揭示了CEND1在皮质祖细胞中驱动细胞周期退出并促进神经元分化的机制。结果显示，CEND1表达上调与神经发生标记物(如β-III微管蛋白)的激活相关。
2. **"Spatiotemporal expression of CEND1 during mouse brain development"**
*Authors: Chen L, et al.*
摘要：通过免疫荧光染色结合CEND1抗体，作者绘制了小鼠胚胎及出生后大脑中CEND1的动态表达图谱，发现其在神经干细胞向神经元分化过渡阶段显著富集，提示其在脑发育中的时序调控作用。
3. **"CEND1 interacts with Notch signaling to balance proliferation and differentiation in neuroblastoma cells"**
*Authors: Rossi M, et al.*
摘要：研究采用CEND1抗体进行免疫共沉淀(Co-IP)和功能缺失实验，证实CEND1通过抑制Notch通路维持神经母细胞瘤细胞的细胞周期退出，为靶向肿瘤干细胞分化提供了潜在策略。
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(提示：实际文献请通过PubMed、Google Scholar等平台以“CEND1 antibody”或“CEND1 neuronal differentiation”等关键词检索。)
The CEND1 antibody targets the CEND1 protein (Cell Cycle Exit and Neuronal Differentiation 1), a key regulator involved in neurogenesis and neuronal maturation. CEND1. also known as BM88. is a neural-specific protein that plays dual roles in promoting cell cycle exit of neuronal precursors and coordinating their differentiation into mature neurons. It is highly expressed during central nervous system development, particularly in the cerebral cortex, hippocampus, and cerebellum.
CEND1 interacts with cell cycle regulators like EZH2 and p27Kip1 to inhibit proliferation while activating differentiation pathways through Notch signaling modulation. Its expression is tightly regulated during brain development and declines postnatally, though it remains detectable in specific adult brain regions.
The CEND1 antibody is widely used in neuroscience research to study neurodevelopmental processes, neural stem cell dynamics, and brain disorders. It enables detection of CEND1 expression patterns via techniques like immunohistochemistry, Western blotting, and flow cytometry. Recent studies utilize this antibody to investigate CEND1's potential role in neurodevelopmental disorders, neurodegenerative diseases, and neural regeneration. Its specificity makes it valuable for identifying neuronal lineage commitment and understanding mechanisms underlying brain development and pathology.
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