关键信息
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基因名
Ab1-40
- 应用
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种属
Human
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表达系统
E. coli
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标签
Two N- s, His- & SUMO-
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05067
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表达区间
Asp672~Val711
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分子量
21kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Research on the Ab1-40 recombinant protein is pivotal in understanding Alzheimer's disease, a neurodegenerative disorder characterized by cognitive decline and memory loss. Ab1-40, a peptide derived from the amyloid precursor protein (APP), plays a significant role in the formation of amyloid plaques, which are hallmark features of the disease. The aggregation of Ab1-40 peptides into oligomers and fibrils is thought to contribute to neurotoxicity and synaptic dysfunction. Recombinant techniques allow for the production of highly pure Ab1-40 peptides, facilitating detailed studies on their structural properties, aggregation kinetics, and interactions with neuronal cells. Investigating the mechanisms underlying Ab1-40 pathology can aid in identifying potential therapeutic targets and biomarkers for Alzheimer's disease. Furthermore, understanding the role of post-translational modifications and mutations in the Ab1-40 sequence could provide insights into the disease's variability and progression. Overall, the study of Ab1-40 recombinant protein is essential for unraveling the complexities of Alzheimer's disease and developing effective treatments.
