| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MSA; TDH2A; TPO; TPX;;Thyroid peroxidase |
| WB Predicted band size | 103 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Thyroid peroxidase |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于TPO抗体的3篇代表性文献摘要示例(内容为模拟生成，非真实文献)：
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1. **文献名称**: *Thyroid Peroxidase Antibodies in Autoimmune Thyroid Disease: A Comprehensive Review*
**作者**: Ruf J, et al. (2017)
**摘要**: 系统分析了TPO抗体在桥本甲状腺炎和Graves病中的病理作用，强调其在甲状腺组织破坏中的核心机制，并讨论了抗体水平与疾病严重程度的相关性。
2. **文献名称**: *Clinical Utility of TPO Antibody Testing in Pregnancy*
**作者**: McLachlan SM, Rapoport B. (2020)
**摘要**: 研究妊娠期女性TPO抗体阳性与流产、早产及产后甲状腺炎风险的关系，建议将TPO抗体筛查纳入高危孕妇的常规检测。
3. **文献名称**: *Advances in TPO Antibody Detection: ELISA vs. Chemiluminescence*
**作者**: Zimmermann MB, et al. (2019)
**摘要**: 比较不同检测方法的灵敏度和特异性，提出新型化学发光法可显著提高TPO抗体低浓度样本的检出率，减少临床误诊。
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注：以上为示例，实际文献需通过PubMed或学术数据库检索确认。
Thyroid peroxidase (TPO) antibodies are autoantibodies targeting thyroid peroxidase, a key enzyme in thyroid hormone synthesis. TPO catalyzes iodide oxidation and thyroglobulin iodination, critical steps in producing thyroxine (T4) and triiodothyronine (T3). In autoimmune thyroid disorders, the immune system mistakenly identifies TPO as foreign, triggering antibody production. Elevated TPO antibodies are hallmark biomarkers of autoimmune thyroid diseases, particularly Hashimoto's thyroiditis (chronic lymphocytic thyroiditis) and Graves' disease. In Hashimoto's, TPO antibodies contribute to glandular destruction and hypothyroidism, while in Graves', they coexist with thyroid-stimulating immunoglobulins driving hyperthyroidism.
TPO antibody testing aids in diagnosing autoimmune thyroid dysfunction, even before symptom onset or abnormal hormone levels. High titers correlate with increased risk of thyroid dysfunction during pregnancy, postpartum thyroiditis, or infertility. Though not exclusive to thyroid autoimmunity, TPO antibodies (present in ~10-15% of euthyroid individuals) indicate genetic predisposition. Detection methods include immunoassays, with high sensitivity/specificity. While TPO antibodies guide clinical decisions, they aren't directly targeted in treatment; management focuses on hormone replacement (e.g., levothyroxine) or anti-thyroid therapies. Research continues to explore their role in predicting disease progression and extra-thyroidal autoimmune manifestations.
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