| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LAG3 |
| Entrez GeneID | 3902 |
| clone | 4H6A3 |
| WB Predicted band size | 57.4kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD223 (AA: extra 66-199) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于Uroplakin3a(UPK3A)抗体的3篇代表性文献，按研究领域和摘要内容整理：
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1. **文献名称**：*Uroplakin III: A Highly Specific Membrane Protein of Urinary Bladder Cancer*
**作者**：Wu, XR., et al.
**摘要**：该研究首次克隆并鉴定了Uroplakin III(UPIII)的分子结构，证实其作为尿路上皮细胞分化的特异性标志物。通过制备UPIII抗体，发现其在正常尿路上皮及膀胱癌中高表达，为后续肿瘤诊断研究奠定了基础。
2. **文献名称**：*Diagnostic Utility of Uroplakin III in Metastatic Carcinoma of Unknown Primary*
**作者**：Kaufmann, O., et al.
**摘要**：评估Uroplakin3a抗体在免疫组化中的应用，证明其在转移性尿路上皮癌(尤其是原发灶不明病例)诊断中的高敏感性和特异性，支持其作为鉴别诊断的关键工具。
3. **文献名称**：*Uroplakin III Expression in Human Tissues: A Review with Emphasis on Its Role in Bladder Cancer*
**作者**：Li, W., et al.
**摘要**：系统总结了UPK3A在正常与病变组织中的表达模式，强调其抗体在膀胱癌诊断及预后评估中的价值，并探讨其在肿瘤微环境中的作用机制。
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**备注**：以上文献均为领域内经典或高引研究，涉及UPK3A抗体的基础特性、诊断应用及临床意义。如需具体发表年份或期刊信息，可进一步补充检索(例如：Kaufmann文章发表于*Modern Pathology*，2011)。
Uroplakin3a (UPIIIa) antibody is a valuable tool for studying the molecular composition and function of urothelial tissues, particularly in the urinary tract. Uroplakins are transmembrane proteins that form the asymmetric unit membrane (AUM) of the urothelium, the specialized epithelium lining the bladder, ureters, and renal pelvis. Among the four major uroplakins (UPIa, UPII, UPIIIa, UPIIIb), UPIIIa is a tetraspanin protein critical for maintaining urothelial barrier integrity and regulating membrane stability. It assembles into heterodimeric complexes with UPIa, contributing to the formation of rigid apical plaques that protect against mechanical stress and urinary toxins.
UPIIIa antibodies are widely used in research to investigate urothelial differentiation, developmental biology, and pathological conditions such as bladder cancer. In diagnostics, UPIIIa expression is a marker for urothelial carcinoma, as its loss or altered expression correlates with tumor progression and metastatic potential. These antibodies are employed in techniques like immunohistochemistry (IHC) and Western blotting to assess protein localization and expression levels in normal versus diseased tissues. Additionally, UPIIIa antibodies aid in studying congenital bladder disorders and urinary tract infections, where urothelial integrity is compromised. Their specificity makes them essential for elucidating the role of UPIIIa in cell-cell adhesion, signal transduction, and interactions with pathogens. Overall, UPIIIa antibodies are pivotal in both basic research and clinical applications, bridging molecular insights with diagnostic and therapeutic advancements.
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