| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AITD3; hTG; TDH3; Tg; TGN; Thyroglobulin;;Thyroglobulin |
| WB Predicted band size | 305 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Thyroglobulin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于甲状腺球蛋白抗体(TgAb)的典型文献概述(基于真实研究方向，具体内容需参考原文)：
1. **《Thyroglobulin Antibody Measurement in the Diagnosis and Management of Thyroid Disease》**
*作者：Spencer CA, et al.*
摘要：探讨TgAb在甲状腺疾病诊断中的临床意义，尤其是对甲状腺功能异常患者和分化型甲状腺癌术后监测的干扰，提出检测标准化的必要性。
2. **《Autoimmune Thyroid Disease: A Comprehensive Review of Pathogenesis and Clinical Implications》**
*作者：Weetman AP.*
摘要：系统回顾甲状腺自身抗体(包括TgAb、TPOAb)在桥本甲状腺炎、Graves病等自身免疫性甲状腺疾病中的致病机制及与疾病活动的相关性。
3. **《Comparison of Thyroglobulin Antibody Assays in Different Clinical Scenarios》**
*作者：Netzel BC, et al.*
摘要：对比多种商业检测试剂盒(如ELISA、化学发光法)的灵敏度和特异性差异，强调临床选择检测方法时需考虑患者群体特征及检测目的。
*注：以上文献为领域内代表性研究方向，实际引用时建议通过PubMed或Google Scholar检索最新文献，优先选择近5年内发表的指南或高引论文。*
Thyroglobulin antibodies (TgAb) are autoantibodies targeting thyroglobulin, a large glycoprotein produced exclusively by thyroid follicular cells. Thyroglobulin serves as a precursor for thyroid hormones (T3/T4) and is stored in colloid within thyroid follicles. In autoimmune thyroid disorders, such as Hashimoto's thyroiditis or Graves' disease, the immune system mistakenly identifies thyroglobulin as foreign, triggering TgAb production. These antibodies are detected in approximately 60-70% of Hashimoto's cases and 30% of Graves' patients, serving as key diagnostic markers for autoimmune thyroid dysfunction.
Clinically, TgAb testing aids in distinguishing autoimmune thyroid conditions from other thyroid pathologies. However, their presence complicates thyroglobulin monitoring in differentiated thyroid cancer (DTC) patients. Since thyroglobulin acts as a tumor marker post-thyroidectomy, TgAb can interfere with immunometric assays, causing falsely low readings. This necessitates simultaneous TgAb measurement during follow-up or alternative testing methods like mass spectrometry.
TgAb prevalence in the general population ranges from 3-27%, influenced by age, sex, and geographic factors. While often associated with hypothyroidism, some TgAb-positive individuals remain euthyroid. Their role in thyroid destruction involves complement activation and antibody-dependent cytotoxicity, contributing to progressive glandular impairment. Current detection methods primarily use immunoassays, though standardization challenges persist across commercial platforms.
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