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Rabbit Monoclonal MRPL11 Antibody

  • 中文名： MRPL11抗体
  • 别    名： CGI113; L11mt; MRP L11;;MRPL11
货号: IPDX18560
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/1000-1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC IHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCGI113; L11mt; MRP L11;;MRPL11
WB Predicted band size21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human MRPL11
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于MRPL11抗体的3篇文献示例(注：文献为模拟生成，仅供参考)：

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1. **文献名称**：*MRPL11 regulates mitochondrial ribosome assembly and mediates apoptosis in colorectal cancer*

**作者**：Zhang Y, et al.

**摘要**：本研究揭示了MRPL11在线粒体核糖体大亚基组装中的关键作用，并发现其在结直肠癌细胞中通过调控Bcl-2/Bax通路促进凋亡。研究通过shRNA敲低MRPL11后，使用特异性抗体(Abcam, ab12345)进行Western blot验证，证实其蛋白表达水平与肿瘤进展相关。

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2. **文献名称**：*Mitochondrial ribosomal protein L11 is required for translational activation of cytochrome c oxidase*

**作者**：Kim SJ, et al.

**摘要**：该文献阐明了MRPL11通过调控细胞色素c氧化酶(COX)的翻译影响线粒体能量代谢。作者利用MRPL11抗体(Proteintech, 6789-T)进行免疫共沉淀实验，证明其与COX亚基mRNA的直接相互作用，为线粒体疾病机制提供了新见解。

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3. **文献名称**：*MRPL11 deficiency disrupts mitochondrial homeostasis and induces cardiomyocyte hypertrophy*

**作者**：Wang L, et al.

**摘要**：研究发现MRPL11缺失导致心肌细胞线粒体功能紊乱和病理性肥大。通过免疫荧光(使用Santa Cruz Biotechnology的sc-555抗体)证实MRPL11定位于线粒体内膜，其表达下降与活性氧(ROS)积累和心肌肥厚表型显著相关。

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**提示**：实际文献需通过PubMed或Google Scholar检索关键词“MRPL11 antibody”或“MRPL11 function”获取，并注意验证抗体的货号及实验应用场景。

背景信息

The MRPL11 antibody is a crucial tool for studying the mitochondrial ribosomal protein L11. a component of the 39S subunit of the mitochondrial ribosome. Mitochondrial ribosomes are responsible for translating mitochondrial DNA-encoded mRNAs, essential for oxidative phosphorylation and cellular energy production. MRPL11 plays a structural and functional role in maintaining ribosome integrity and facilitating protein synthesis within mitochondria. Dysregulation of mitochondrial ribosomal proteins, including MRPL11. has been linked to mitochondrial disorders, cancer, and neurodegenerative diseases. The MRPL11 antibody enables researchers to detect and quantify MRPL11 expression in various experimental settings, such as Western blotting, immunohistochemistry, and immunofluorescence. It is particularly valuable in investigating mitochondrial dysfunction, assessing tissue-specific expression patterns, and exploring molecular mechanisms underlying diseases associated with impaired mitochondrial translation. Recent studies have also suggested its potential role in cellular stress responses and apoptosis regulation. Validating MRPL11 antibody specificity through knockdown controls or mass spectrometry is critical, as cross-reactivity with homologous cytosolic ribosomal proteins may occur. This antibody supports advances in understanding mitochondrial biology and its implications in health and disease.

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